β-arrestin: Dr Jekyll and Mr Hyde in NASH and fibrosis

Non-alcoholic fatty liver disease (NAFLD) is a multifactorial disorder of hepatic lipid metabolism that leads to steatosis, and can progress to cirrhosis and hepatocellular carcinoma, usually in conjunction with over-nutrition and the metabolic syndrome.1 A central molecular driver of progression is lipotoxicity, a process involving multiple lipid species and pathways that result in hepatocyte damage, liver inflammation and fibrogenesis.2

Source: Journal of Hepatology - February 27, 2020 Category: Gastroenterology Authors: Hiroyuki Abe, Detlef Schuppan Tags: Editorial Source Type: research