A Plasmodium key fits a mosquito lock Microbiology

Malaria is one of the three most lethal infectious diseases. Unlike AIDS and tuberculosis, malaria is unique in that the parasite must complete a complex differentiation program in its mosquito vector for transmission to occur (1) (Fig. 1). Despite significant progress made in the last couple of decades, our mechanistic...
Source: Proceedings of the National Academy of Sciences - Category: Science Authors: Tags: Commentaries Source Type: research

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Conclusions Toxoplasma gondii infection induces a strong innate and adaptive immune response. While the innate immunity is important for controlling the early stages of the infection (Yarovinsky, 2014), the adaptive immunity is critical for restricting the parasite replication during the later stages (Gazzinelli et al., 1992). Amongst the adaptive immune subsets, CD8 T cells are the primary effector cells while CD4 T cells play an essential helper role to maintain long-term immunity (Casciotti et al., 2002). Notwithstanding, a robust CD8 T cell immunity induced during acute phase of infection, does not result in the total...
Source: Frontiers in cellular and infection microbiology - Category: Microbiology Source Type: research
Jeffrey G. Shaffer1*, Frances J. Mather1, Mamadou Wele2, Jian Li1, Cheick Oumar Tangara2, Yaya Kassogue2, Sudesh K. Srivastav1, Oumar Thiero2, Mahamadou Diakite2, Modibo Sangare2, Djeneba Dabitao2, Mahamoudou Toure2, Abdoulaye A. Djimde2, Sekou Traore2, Brehima Diakite2, Mamadou B. Coulibaly2, Yaozhong Liu1, Michelle Lacey3, John J. Lefante1, Ousmane Koita2, John S. Schieffelin4, Donald J. Krogstad1 and Seydou O. Doumbia2 1Department of Global Biostatistics and Data Science, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA, United States 2Faculty of Medicine and Odontostomatology, Un...
Source: Frontiers in Genetics - Category: Genetics & Stem Cells Source Type: research
(CNN) — From climate change to superbugs, the World Health Organization has laid out 10 big threats to our global health in 2019. And unless these threats get addressed, millions of lives will be in jeopardy. Here’s a snapshot of 10 urgent health issues, according to the United Nations’ public health agency: Not vaccinating when you can One of the most controversial recent health topics in the US is now an international concern. “Vaccine hesitancy — the reluctance or refusal to vaccinate despite the availability of vaccines — threatens to reverse progress made in tackling vaccine-prevent...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - Category: Consumer Health News Authors: Tags: Health News CNN Local TV Source Type: news
We’re excited to share the topic and questions for this week’s #HITsm chat happening Friday, 11/30 at Noon ET (9 AM PT). This week’s chat will be hosted by Vanessa Carter (@_FaceSA) on the topic of “The Global Impact of Health IT”. Global health pandemics like antibiotic and antimicrobial resistance are among the most critical issues to tackle and in future will require robust, harmonious data surveillance systems along with mass co-operation between the animal, human and environmental health sectors across every country [1]. This is known as One Health [2]. WHO initiatives like GLAS...
Source: EMR and HIPAA - Category: Information Technology Authors: Tags: #HITsm Healthcare Healthcare AI HealthCare IT #HITsm Topics Antibiotic Resistance GLASS Global Antimicrobial Resistance Surveillance System Global Health One Health Vanessa Carter Source Type: blogs
Malaria, together with HIV/AIDS, tuberculosis and hepatitis are the four most deadly infectious diseases globally. Progress in eliminating malaria has saved millions of lives, but also creates new challenges i...
Source: Malaria Journal - Category: Infectious Diseases Authors: Tags: Review Source Type: research
LITFL • Life in the Fast Lane Medical Blog LITFL • Life in the Fast Lane Medical Blog - Emergency medicine and critical care medical education blog aka Tropical Travel Trouble 009 The diagnosis of HIV is no longer fatal and the term AIDS is becoming less frequent. In many countries, people with HIV are living longer than those with diabetes. This post will hopefully teach the basics of a complex disease and demystify some of the potential diseases you need to consider in those who are severely immunosuppressed. While trying to be comprehensive this post can not be exhaustive (as you can imagine any patient with ...
Source: Life in the Fast Lane - Category: Emergency Medicine Authors: Tags: Clinical Cases Tropical Medicine AIDS art cryptococcoma cryptococcus HIV HIV1 HIV2 PEP PrEP TB toxoplasma tuberculoma Source Type: blogs
AbstractAlthough the focus in the area of health research may be shifting from infectious to non-communicable diseases, the infectious diseases of poverty remain a major burden of disease of global health concern. A global platform to communicate and share the research on these diseases is needed to facilitate the translation of knowledge into effective approaches and tools for their elimination. Based on the “One health, One world” mission, a new, open-access journal,Infectious Diseases of Poverty (IDP), was launched by BioMed Central in partnership with the National Institute of Parasitic Diseases (NIPD), Chi...
Source: Infectious Diseases of Poverty - Category: Infectious Diseases Source Type: research
DAVOS, Switzerland, Jan 20 (Reuters)- When it comes to fighting malaria, Bill Gates and Ray Chambers are both inspired and concerned: With victory in sight, will the world’s new leaders commit to finally beating this persistent parasite? In exclusive interviews with Reuters in Davos, Gates and Chambers both voiced concern about leadership changes in the U.S. and in United Nations bodies and what these might mean for funding and commitment to global health. “The imponderable is what happens with President Trump,” said Chambers, the United Nations special envoy for malaria. “We’re just not sure....
Source: Healthy Living - The Huffington Post - Category: Consumer Health News Source Type: news
Mankind vs. Pathogen. This idea--the ages-old, microscopic battle between parasites, bacteria, viruses and human immune systems--is the essence of the science performed by myself and so many other infectious disease researchers. Winning this battle, advancing the knowledge and cures necessary to ultimately defeat global diseases, is precisely where our work is focused. Inspired by the battle our scientists wage against deadly disease-causing pathogens, we have developed a series of posters to capture the spirit of this battle of "Human vs. Pathogen". Our aim is to highlight the creativity, imagination, and pa...
Source: Science - The Huffington Post - Category: Science Source Type: news
Abstract The peer-reviewed journal Infectious Diseases of Poverty provides a new platform to engage with, and disseminate in an open-access format, science outside traditional disciplinary boundaries. The current piece reviews a thematic series on surveillance-response systems for elimination of tropical diseases. Overall, 22 contributions covering a broad array of diseases are featured – i.e. clonorchiasis, dengue, hepatitis, human immunodeficiency virus/acquired immune deficiency syndrome (HIV/AIDS), H7N9 avian influenza, lymphatic filariasis, malaria, Middle East respiratory syndrome (MERS), rabies, schi...
Source: Infectious Diseases of Poverty - Category: Infectious Diseases Source Type: research
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