pH-sensitive CuS@Cu2S@Au nanoparticles as a drug delivery system for the chemotherapy against colon cancer.

pH-sensitive CuS@Cu2S@Au nanoparticles as a drug delivery system for the chemotherapy against colon cancer. Biochem Biophys Res Commun. 2020 Feb 19;: Authors: Yan E, Zhang Z Abstract pH-sensitive CuS@Cu2S@Au nanoparticles (NPs) are successfully prepared by sacrificing template method. The NPs are of hollow structure, which is certified by transmission electron microscopy (TEM). The CuS@Cu2S@Au NPs can be used as carriers for doxorubicin (DOX). The DOX loaded NPs exhibit pH-sensitive release of the drug, which are prospective as controllable drug delivery system. Besides, relative to the high toxicity and lethality of the free DOX, the time-dependent release of drug from the NPs is more suitable for the long-time and lasting treatment for colon cancer. The CuS@Cu2S@Au NPs with good biocompatibility are promising biomaterials in the application of biomedical and tissue engineering fields. PMID: 32087962 [PubMed - as supplied by publisher]
Source: Biochemical and Biophysical Research communications - Category: Biochemistry Authors: Tags: Biochem Biophys Res Commun Source Type: research