MicroRNA-429 inhibits neuroblastoma cell proliferation, migration and invasion via the NF- κB pathway.

Conclusion: We provide important insight into miR-429 as a tumor suppressor through interaction with IKKβ, which is a catalytic subunit of the IKK complex that activates NF-κB nuclear transport. Our results demonstrate that miR-429 may be a new target for the treatment of neuroblastoma. PMID: 32082390 [PubMed - in process]
Source: Cellular and Molecular Biology Letters - Category: Biochemistry Authors: Tags: Cell Mol Biol Lett Source Type: research

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This video covers key aspects of neuroblastoma, including the causes, symptoms, diagnosis, and treatment.Osmosis
Source: Medscape Today Headlines - Category: Consumer Health News Tags: Med Students Commentary Source Type: news
We identified 20 survival ‐related long noncoding RNAs (lncRNAs) that might be associated with the spontaneous regression of neuroblastoma (NB) and developed a four‐lncRNA signature risk score. The four‐lncRNA signature is an independent prognostic factor of survival in NB. AbstractBackgroundThe association between long noncoding RNAs (lncRNAs) and spontaneous regression of neuroblastoma (NB) has rarely been investigated and remains unknown.ObjectiveTo identify prognostic lncRNAs involved in the spontaneous regression of NB.MethodsDifferential expression analyses were performed between those samples with an outcome o...
Source: Cancer Medicine - Category: Cancer & Oncology Authors: Tags: ORIGINAL RESEARCH Source Type: research
Chemical Research in ToxicologyDOI: 10.1021/acs.chemrestox.9b00437
Source: Chemical Research in Toxicology - Category: Toxicology Authors: Source Type: research
In this study, 4‐F4t‐NeuroP was introduced into neuroblastoma cells (SH‐SY5Y) and, byin vivo infusion, into rodents. Targeted lipidomic analysis of liver and brain tissues show significant elevation of anti ‐inflammatory hydroxylated‐DHA metabolites and an isomer of neuroprotectin D1, suggesting potential beneficial bioactivities of 4‐F4t‐NeuroP. Additionally, 4‐F4t‐NeuroP treatment in SH‐SY5Y cells and primary neuronal culture consistently upregulates the transcriptional level of the antioxidant enzyme hemeoxygenase‐1, but the effect is reduced when 4‐F4t‐NeuroP is further oxidized. Our data sugg...
Source: FEBS Letters - Category: Biochemistry Authors: Tags: COMMUNICATION Source Type: research
Aerobic glycolysis is a hallmark of metabolic reprogramming that contributes to tumor progression. However, the mechanisms regulating expression of glycolytic genes in neuroblastoma (NB), the most common extra...
Source: Journal of Hematology and Oncology - Category: Hematology Authors: Tags: Research Source Type: research
AbstractObjectiveThe aim of the study was to investigate the outcomes and prognostic factors of high-dose131I-metaiodobenzylguanidine (131I-MIBG) therapy in patients with refractory or relapsed neuroblastoma (NBL) in Japan.MethodsWe retrospectively analyzed 20 patients with refractory or relapsed high-risk NBL who underwent131I-MIBG therapy with an administration dose ranging from 444 to 666  MBq/kg at Kanazawa University Hospital, Japan, between September 2008 and September 2013. We focused on measurements regarding their initial responses, prognostic factors, survivals, and toxicities following131I-MIBG therapy usin...
Source: Annals of Nuclear Medicine - Category: Nuclear Medicine Source Type: research
Conditions:   Hematopoietic and Lymphoid Cell Neoplasm;   Recurrent Ependymoma;   Recurrent Ewing Sarcoma;   Recurrent Hepatoblastoma;   Recurrent Histiocytic and Dendritic Cell Neoplasm;   Recurrent Langerhans Cell Histiocytosis;   Recurrent Lymphoma;   Recurrent Malignant Germ Cel l Tumor;   Recurrent Malignant Glioma;   Recurrent Malignant Solid Neoplasm;   Recurrent Medulloblastoma;   Recurrent Neuroblastoma;   Recurr...
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Neuroblastoma (NB) tumor rupture is a rare oncology emergency with a poor prognosis. We aimed to evaluate patient clinical characteristics and risk factors for ruptured NB.
Source: BMC Cancer - Category: Cancer & Oncology Authors: Tags: Research article Source Type: research
Wild boar-derived hepatitis E (HEV) genotype 3 virus has been successfully isolated in cell lines of human origin only. Considering the zoonotic potential and possible extrahepatic localisation of genotype 3 s...
Source: BMC Veterinary Research - Category: Veterinary Research Authors: Tags: Research article Source Type: research
Contributors : Tao Liu ; Andrew Tee ; Matthew Wong ; Nicolas HoSeries Type : Expression profiling by arrayOrganism : Homo sapiensThe CDK7 inhibitor THZ1 has been shown to suppress MYCN gene transcription but not cause significant cell death as a single agent.The tyrosine kinase inhibitors (TKIs) ponatinib and lapatinib were found to exert synergistic anti-cancer effects in combination with the CDK7 inhibitor THZ1, on MYCN amplified neuroblastoma cell lines.
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by array Homo sapiens Source Type: research
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