MicroRNA-429 inhibits neuroblastoma cell proliferation, migration and invasion via the NF- κB pathway.

Conclusion: We provide important insight into miR-429 as a tumor suppressor through interaction with IKKβ, which is a catalytic subunit of the IKK complex that activates NF-κB nuclear transport. Our results demonstrate that miR-429 may be a new target for the treatment of neuroblastoma.
PMID: 32082390 [PubMed - in process]

Source: Cellular and Molecular Biology Letters - February 24, 2020 Category: Biochemistry Authors: Zhou X, Lu H, Li F, Hao X, Han L, Dong Q, Chen X Tags: Cell Mol Biol Lett Source Type: research