Chemerin in immune response and gastrointestinal pathophysiology.

Chemerin in immune response and gastrointestinal pathophysiology.
Clin Chim Acta. 2020 Feb 15;504:146-153
Authors: Jacenik D, Fichna J
Abstract
Chemerin is a multifunctional protein involved among others in adipogenesis, angiogenesis and lipid as well as glucose metabolism. Chemerin is an essential factor in promotion of chemotaxis of numerous immune cell types and plays an important role in several pathophysiologic conditions. Chemerin receptors are present on monocytes/macrophages, T cells, natural killer and dendritic cells as well as neutrophils. However, the role of chemerin and chemerin receptors in immune response and gastrointestinal diseases is still poorly understood. Accumulating, clinical and experimental studies observed disturbation of chemerin and chemerin receptors in a number of disorders including Barrett's esophagus, esophageal cancer, gastric cancer, hepatic dysfunction, irritable bowel syndrome, inflammatory bowel disease and colorectal cancer. Moreover, chemerin and chemerin receptors have been shown to regulate proliferation, migration and invasion of gastrointestinal and immune cells as well as cancer-associated fibroblasts. In this review we present the current state of knowledge about the contribution of chemerin to immune response and gastrointestinal disorders.
PMID: 32070869 [PubMed - as supplied by publisher]

Source: International Journal of Clinical Chemistry - February 14, 2020 Category: Chemistry Authors: Jacenik D, Fichna J Tags: Clin Chim Acta Source Type: research