Combined Effect of Omega-3 Fatty Acids and Phytosterol Ester on alleviating Hepatic Steatosis in NAFLD Subjects: A Double-blind Placebo-controlled Clinical Trial.

In conclusion, co-supplementation of PS and EPA+DHA could increase the effectiveness of treatment for hepatic steatosis. PMID: 32054543 [PubMed - as supplied by publisher]
Source: The British Journal of Nutrition - Category: Nutrition Authors: Tags: Br J Nutr Source Type: research

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Condition:   Non-alcoholic Fatty Liver Disease (NAFLD) Interventions:   Drug: Metabolic Cofactor Supplementation;   Drug: Sorbitol Sponsors:   ScandiBio Therapeutics AB;   Koç University;   Koç University Hospital;   Göteborg University;   Sahlgrenska University Hospital, Sweden;   KTH Royal Institute of Technology;   University of Helsinki;   Helsinki University Central Hospital;   Monitor CRO Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conclusions: The prevalence of suspected NAFLD continues to increase in Korean adolescents.Abbreviations: ALT, alanine aminotransferase; BMI, body mass index; KNHANES, Korea National Health and Nutrition Examination Survey; NAFLD, non-alcoholic fatty liver disease. PMID: 32223545 [PubMed - as supplied by publisher]
Source: Paediatrics and international child health - Category: Pediatrics Tags: Paediatr Int Child Health Source Type: research
This study was conducted among 160 diabetic patients with NAFLD proven biopsy. Anthropometric assessments, laboratory test, liver histological features and follow-up of a Mediterranean diet were evaluated.ResultsDiabetic patients with liver fibrosis showed a greater number of positive metabolic criteria than diabetic patients without liver fibrosis. Patients with hepatic fibrosis have a lower score on the PREDIMED test (9.0 (2.4) vs. 6.2 (2.3);p 
Source: Endocrine - Category: Endocrinology Source Type: research
AbstractUrsodeoxycholic acid (UDCA) is a secondary bile acid that is used to treat primary biliary cholangitis. Although UDCA has a hepatoprotective effect in some diseases, its benefit in nonalcoholic fatty liver disease (NAFLD) remains controversial. We aimed to evaluate the pharmacokinetics (PK) and pharmacodynamics (PD) of UDCA in overweight subjects with elevated liver enzymes after multiple administrations of UDCA and compare these changes with vitamin E treatment. Overweight subjects (body mass index, 25 ‐30 kg/m2) with elevated alanine aminotransferase (ALT) level (40 ‐200 IU/L) were enrolled. Subject...
Source: Clinical Pharmacology in Drug Development - Category: Drugs & Pharmacology Authors: Tags: Original Manuscript Source Type: research
Weight loss by ketogenic diet (KD) has gained popularity in management of nonalcoholic fatty liver disease (NAFLD). KD rapidly reverses NAFLD and insulin resistance despite increasing circulating nonesterified fatty acids (NEFA), the main substrate for synthesis of intrahepatic triglycerides (IHTG). To explore the underlying mechanism, we quantified hepatic mitochondrial fluxes...
Source: Proceedings of the National Academy of Sciences - Category: Science Authors: Tags: Biological Sciences Source Type: research
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Source: Archives of Physiology and Biochemistry - Category: Physiology Authors: Source Type: research
Authors: Shibayama Y, Wada N, Baba S, Obara S, Sakai H, Usubuchi H, Terae S, Nakamura A, Atsumi T Abstract Patients with primary aldosteronism (PA) are complicated by metabolic syndrome more frequently than those without PA. Hyperaldosteronism has been reported to be associated with a higher prevalence of non-alcoholic fatty liver disease (NAFLD). We aimed to clarify the risk factors for hepatic steatosis in the two subtypes of PA, comparing the status of hepatic steatosis in each of these subtypes. This was a retrospective observational study. We enrolled patients with an aldosterone producing adenoma (APA) (n = 3...
Source: Endocrine Journal - Category: Endocrinology Tags: Endocr J Source Type: research
We present an up-to-date systematic review of the current literature regarding the safety in artificial and natural sweeteners use as a means of weight loss or diabetes control.Expert opinion: Natural sweeteners have not been associated directly with NAFLD, and on the contrary, some, such as stevia, and trehalose, may have a protective effect. Rare sugars and polyols can be used safely and have significant benefits that include anti-oxidant effect and optimal glycemic control. Artificial sweeteners, due to their effect on NAFLD development and insulin resistance, are not indicated in patients with obesity or diabetes. Furt...
Source: Expert Review of Endocrinology and Metabolism - Category: Endocrinology Tags: Expert Rev Endocrinol Metab Source Type: research
Conclusion: Serum GGT level was a significant predictor of subsequent risk of diabetes mellitus, which increased by 4% for every 1 IU/L increase in GGT when GGT was less than 24 IU/L. PMID: 32215009 [PubMed]
Source: International Journal of Endocrinology - Category: Endocrinology Tags: Int J Endocrinol Source Type: research
AbstractIntroductionInsulin resistance (IR) plays a central role in pathogenesis of nonalcoholic steatohepatitis (NASH). The aim of this study was to correlate histopathological grading and IR in overweight/obese patients with NASH as compared with lean NASH.MethodsPatients with NASH who underwent liver biopsy between January 2012 and December 2012 were included. Anthropometric, clinical, and biochemical features, necro-inflammatory grades, and fibrosis stage on liver biopsies were scored according to Brunt and non-alcoholic fatty liver disease (NAFLD) activity score (NAS).ResultsOf 42 patients, 33 (78.6%) had body mass in...
Source: Indian Journal of Gastroenterology - Category: Gastroenterology Source Type: research
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