Antagonistic effect of colistin on vancomycin activity against methicillin-resistant Staphylococcus aureus in in vitro and in vivo studies.

This study suggests that exposure of colistin may reduce the susceptibility of vancomycin in certain MRSA strains. Combination therapy with vancomycin and colistin for multidrug-resistant pathogens might result in treatment failure for concurrent MRSA infection.
PMID: 32041713 [PubMed - as supplied by publisher]

Source: Antimicrobial Agents and Chemotherapy - February 9, 2020 Category: Microbiology Authors: Choi S, Moon SM, Park SJ, Lee SC, Jung KH, Sung HS, Kim MN, Jung J, Kim MJ, Kim SH, Lee SO, Choi SH, Jeong JY, Woo JH, Kim YS, Chong YP Tags: Antimicrob Agents Chemother Source Type: research