Genomic and Transcriptomic Characterization of Sporadic Medullary Thyroid Carcinoma.

Conclusion:</b> In addition to RET, our research also shows there may be high-frequency FAT1/FAT4 genomic alterations in sMTC. Two molecular subtypes of sMTC with distinct biological behaviors are also identified. However, our results need to be validated by larger samples and more comprehensive experiments in the future, especially for the frequency and function of FAT1/FAT4 germline variants. PMID: 32031055 [PubMed - as supplied by publisher]
Source: Thyroid : official journal of the American Thyroid Association - Category: Endocrinology Tags: Thyroid Source Type: research