‘It’s Insidious’: How Juul Pitched E-Cigs to Native American Tribes

New Congressional documents reveal that e-cigarette maker Juul Labs pitched its products to at least eight Native American tribes, in a move tribal health advocates say is as disturbing as it is expected. “I always suspected that the targeting of tribes was more pervasive than we knew,” says Rae O’Leary, a public health analyst who founded the anti-tobacco Canli Coalition of the Cheyenne River Sioux Tribe (CRST) and in July testified before Congress about Juul’s outreach to the CRST. “It’s saddening. The tobacco industry and the e-cigarette industry see us as a vulnerable population, one they can take advantage of.” The new documents, released Feb. 5 by the Congressional Subcommittee on Economic and Consumer Policy, build on O’Leary’s testimony, illustrating the extent to which Juul sought to implement “switching programs” and sales partnerships with numerous tribes—an approach that advocates and lawmakers find eerily reminiscent of Big Tobacco strategies. “Big Tobacco targeted Native Americans and caused them to have the highest rate of tobacco use in America,” Rep. Raja Krishnamoorthi, chairman of the Subcommittee, said in a statement provided to TIME. “It is disturbing to see JUUL following in Big Tobacco’s footsteps by preying on Native American communities.” Juul did not respond to TIME’s request for comment. Smoking rates in the U.S. have declined dramatically in...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized E-Cigarettes public health Source Type: news

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Abstract The critical role of metabolism in facilitating cancer cell growth and survival has been demonstrated by a combination of methods including, but not limited to, genomic sequencing, transcriptomic and proteomic analyses, measurements of radio-labelled substrate flux and the high throughput measurement of oxidative metabolism in unlabelled live cells using the Seahorse Extracellular Flux (XF) technology. These studies have revealed that tumour cells exhibit a dynamic metabolic plasticity, using numerous pathways including both glycolysis and mitochondrial oxidative phosphorylation (OXPHOS) to support cell p...
Source: Mol Biol Cell - Category: Molecular Biology Authors: Tags: Methods Mol Biol Source Type: research
The prognosis of advanced non-small –cell lung cancer (NSCLC) has been dramatically improved by promising new treatments: targeted therapies for oncogenic addictions and immune-checkpoint inhibitors (ICIs), including anti-programmed cell-death protein-1 (PD-1) nivolumab and pembrolizumab.
Source: Lung Cancer - Category: Cancer & Oncology Authors: Source Type: research
The objective was to compare end-of-life care delivered to patients with schizophrenia and lung cancer with patients without severe mental disorder. This population-based cohort study included all patients aged 15 and older who died from their terminal lung cancer in hospital in France (2014-2016). Schizophrenia patients and controls without severe mental disorder were selected and indicators of palliative care and high-intensity end-of-life care were compared. Multivariable generalized log-linear models were performed, adjusted for sex, age, year of death, social deprivation, time between cancer diagnosis and death, metas...
Source: European Archives of Psychiatry and Clinical Neuroscience - Category: Psychiatry Tags: Eur Arch Psychiatry Clin Neurosci Source Type: research
The objective was to compare end-of-life care delivered to patients with schizophrenia and lung cancer with patients without severe mental disorder. This population-based cohort study included all patients aged 15 and older who died from their terminal lung cancer in hospital in France (2014 –2016). Schizophrenia patients and controls without severe mental disorder were selected and indicators of palliative care and high-intensity end-of-life care were compared. Multivariable generalized log-linear models were performed, adjusted for sex, age, year of death, social deprivation, time b etween cancer diagnosis and deat...
Source: European Archives of Psychiatry and Clinical Neuroscience - Category: Neuroscience Source Type: research
Conclusion: Our study confirmed the activity and safety of metronomic oral vinorelbine in patients with wild-type local/advanced and metastatic NSCLC unsuitable for treatment with standard i.v. chemotherapy, allowing patients a comfortable home-based therapy, thereby avoiding frequent hospital visits.
Source: In Vivo - Category: Research Authors: Tags: Clinical Studies Source Type: research
Celecoxib has potential as an effective antineoplastic agent, but it may exhibit side effects. Given the glucose-addicted properties of tumor cells, metformin is recognized for its inhibitory effect on oxidative phosphorylation. In the present study, we aimed to combine low dose of celecoxib with metformin to alleviate the side effects of nonsteroidal anti-inflammatory drugs (NSAIDs) and overcome potential drug resistance. We found that celecoxib combined with metformin obviously suppressed cell migration and proliferation and induced cell apoptosis. Most importantly, in vivo experiments revealed the superior antitumor eff...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
  At one point, Gabe weighed more than 550 pounds. Today, he and Lisa remember and discuss the extreme pain and slow healing process of living with binge-eating disorder. Gabe shares his shame in being so overweight, his intense relationship with food, the story of his gastric bypass and the difficult process of learning new coping mechanisms. How did Gabe’s bipolar and panic attacks tie in with his binge eating? And, importantly, how is he managing the illness today? Join us for an open and honest discussion on living with an eating disorder. (Transcript Available Below) Please Subscribe to Our Show: And We...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Binge Eating Disorders Eating Disorders General Not Crazy Podcast Source Type: blogs
Conclusions: We find that the combination of microtubule stabilizing agent and lysosome inhibitor could reduce the tumor progression in EGFR TKI resistant mouse models of lung cancer.
Source: Theranostics - Category: Molecular Biology Authors: Tags: Research Paper Source Type: research
Lung cancer is the leading cause of cancer death worldwide. Cigarette smoking is the most common risk factor for lung carcinoma; other risks include genetic factors and exposure to radon gas, asbestos, secondhand smoke, and air pollution. Nicotine, the primary addictive constituent of cigarettes, contributes to cancer progression through activation of nicotinic acetylcholine receptors (nAChRs), which are membrane ligand-gated ion channels. Activation of nicotine/nAChR signaling is associated with lung cancer risk and drug resistance. We focused on nAChR pathways activated by nicotine and its downstream signaling involved i...
Source: Journal of Cancer - Category: Cancer & Oncology Authors: Tags: Review Source Type: research
Abstract BACKGROUND: Over decades, there have been several alterations to cigarettes, including the addition of filters and flavoring. Despite this, lung cancer remains the leading cause of cancer-related death in the US. We aimed to examine the association of type of cigarette on nicotine dependence in the setting of lung cancer screening. METHODS: This is a secondary analysis of the American College of Radiology Imaging Network arm of the National Lung Screening Trial. Tobacco dependence was evaluated using the Fagerstrӧm Test for Nicotine Dependence, the Heaviness of Smoking Index, and time to first cigar...
Source: Chest - Category: Respiratory Medicine Authors: Tags: Chest Source Type: research
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