Biogenic Ag/CaO nanocomposites kill Staphylococcus aureus with reduced toxicity towards mammalian cells

Publication date: Available online 4 February 2020Source: Colloids and Surfaces B: BiointerfacesAuthor(s): Md. Imran Khan, Ankit Mazumdar, Soumitra Pathak, Prajita Paul, Susanta Kumar Behera, Ashok J. Tamhankar, Suraj K. Tripathy, Cecilia Stålsby Lundborg, Amrita MishraAbstractRapid increase in the case of bacterial infections is considered as a major public health concern and hence exploration of alternative treatment procedures including development of nanomaterials based therapeutic strategies is receiving much attention. In this aspect, here we investigated the antibacterial efficacy of a simple and potential metal/metal oxide nanocomposite system. Biogenic synthetic protocol was designed for processing of Ag/CaO nanocomposites (NCs). Structural features and morphology of the synthesized nanomaterials were investigated by X-ray diffraction (XRD) and electron microscopy techniques respectively. Optical properties of the nanomaterials were analyzed by UV-vis spectrophotometer. Presence of water and possible impurity molecules on the materials surface was examined by Fourier-transform infrared spectroscopy (FTIR). Effective antibacterial activity of the NCs was observed (within a range of 25-150 µg/mL of NCs) against Staphylococcus aureus (S. aureus) and Methicillin-resistant Staphylococcus aureus (MRSA). The potential anti-biofilm effect of as synthesized NCs was tested against S. aureus. Experimental results suggest that the antibacterial action of the NCs could be due...
Source: Colloids and Surfaces B: Biointerfaces - Category: Biochemistry Source Type: research