Construction of antimicrobial and biocompatible cotton textile based on quaternary ammonium salt from rosin acid.

In this study, the surface of CT was modified using maleopimaric acid quaternary ammonium cations (MPA-N+) from rosin acid. The surfaces morphology and chemical composition were determined by scanning electron microscopy (SEM) and X-ray photoelectron spectroscopy (XPS), which confirmed that the MPA-N+ modified CT (CT-g-MPA-N+) was prepared. CT-g-MPA-N+ shows strong and broad spectrum antimicrobial activities against Gram-negative bacteria (Escherichia coli, Pseudomonas aeruginosa) and Gram-positive bacteria (Staphylococcus aureus). It also exhibits prominent durability of antimicrobial capability even after soaking in PBS for 6 days, and can effectively inhibit bacterial biofilm formation. Most importantly, the excellent biocompatibility of CT-g-MPA-N+ was verified by hemocompatible and cytotoxic assays. This work is believed to be promising method to prepare antimicrobial cotton textiles by surface modification and suggest the great potential application in wound dressing. PMID: 32007552 [PubMed - as supplied by publisher]
Source: International Journal of Biological Macromolecules - Category: Biochemistry Authors: Tags: Int J Biol Macromol Source Type: research