Association between pelvic inflammatory disease, infertility, ectopic pregnancy and the development of ovarian serous borderline tumor, mucinous borderline tumor and low-grade serous carcinoma.
CONCLUSIONS: The association with PID supports the hypothesis that inflammatory processes within the upper gynaecological tract and/or peritoneum may predispose to the development of SBT and LGSC. PMID: 31983516 [PubMed - as supplied by publisher]
Purpose: Immune checkpoint inhibitors (ICI) are now standard of care for advanced urothelial carcinoma (UC) that have failed platinum therapy. Atezolizumab and pembrolizumab are also approved in the first line setting for patients who are cisplatin-ineligible and are PD-L1 positive. This retrospective observational study aimed to describe the safety and efficacy of the ICI pembrolizumab in the real world setting at Guy ’s Hospital.
Purpose: Sunitinib and pazopanib are standards of care for the first line treatment of metastatic renal cell carcinoma (mRCC) across the world. A phase III clinical trial has shown that pazopanib is non-inferior to sunitinib as first line treatment for mRCC. However, it is likely that the comparative efficacy of these drugs may differ in real world clinical practice. We aim to evaluate the outcomes and compare toxicities of patients with mRCC treated with first line sunitinib or pazopanib in regular clinical practice.
Purpose: The management of metastatic urothelial cancer (mUC) is challenging. It is predominately a disease of the elderly population. The median age in the UK at which patients present with urothelial carcinoma is over 70 years. A large population of patients is unsuitable for cisplatin based therapy due to poor performance status and medical comorbidities. Overall outcome was poor due to limited treatment options. Recently, immune checkpoint inhibitors have improved disease response and survival.
Authors: Jia M, Xiong Y, Li M, Mao Q Abstract Chemotherapy is critical for the treatment of hepatocellular carcinoma (HCC). Despite the pro-apoptotic effects of corosolic acid (CA) treatment, its underlying mechanism is not completely clear. The aim of this study was to determine the molecular mechanism of CA in HCC treatment. MTT assay was used to determine the IC50 of CA. Immunoprecipitation and immunofluorescence were used to detect the interaction between and subcellular localization of Yes-associated protein (YAP) and mouse double minute 2 (MDM2). In addition, in vivo xenotransplantation was performed to asses...
Publication date: Available online 29 March 2020Source: Biochimica et Biophysica Acta (BBA) - Reviews on CancerAuthor(s): Yuting Jiang, Chengdi Wang, Shengtao Zhou
In conclusion, when treating elderly men with a smoking history, physicians need to carefully examine the walls of cystic airspaces on CT for fetal adenocarcinoma.Key pointsSignificant findings of the study•Pulmonary high‐grade fetal adenocarcinoma may be associated with emphysematous bullae manifesting as cystic air spaces as shown by computed tomography.What this study adds•When scanning by computed tomography, physicians should carefully examine the pulmonary cystic airspace walls in elderly men with a smoking history.
AbstractThis journal recently published a paper by Sharpe et al., entitled “Necessary components of psychological treatments in chronic pain management programs: A Delphi study” (Sharpe, Jones, Ashton‐James, Nicholas,&Refshauge, 2020). These researcher sought the views of authors of relevant RCTs published up to September 2016 and supplemented these with input from psychologists working in pain management programs in Australia.
This article argues that child protection agencies must provide mandatory training about the Aboriginal experience within the welfare state and the resultant trauma that exists in Australian Indigenous communities. This article highlights the areas of curriculum to be included in training for welfare practitioners working with Aboriginal families in the New South Wales child protection system. The training content explores the Stolen Generations ’ trauma experiences of child loss and examines the dichotomy between past child welfare laws and present child protection laws and intergenerational racism. Another key comp...
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