Endothelin-1 and Conflicting Risk Association: A New Lens A Response to Leary et al, “Endothelin-1, cardiac morphology, and heart failure: the MESA angiogenesis study.”

I read with interest the original science study by Leary et al entitled “Endothelin-1, cardiac morphology, and heart failure: the MESA angiogenesis study.1” The authors are to be congratulated for their thoughtful work pursuing the association of endothelin-1 (ET1) with cardiovascular risk in a population free from clinical cardiovascular disease at enrollment. Furt her, their counter-intuitive findings that higher ET1 were associated with higher ejection fraction and reduced risk for heart failure or cardiovascular death are thought-provoking.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: Case Anecdotes, Comments and Opinions Source Type: research