The effect of positive end-expiratory pressure on stroke volume variation: an experimental study in dogs.

The effect of positive end-expiratory pressure on stroke volume variation: an experimental study in dogs. Clin Exp Pharmacol Physiol. 2020 Jan 26;: Authors: Nakashima T, Kawazoe Y, Iseri T, Miyamoto K, Fujimoto Y, Kato S Abstract Stroke volume variation (SVV) may be affected by ventilation settings. However, it is unclear whether positive end-expiratory pressure (PEEP) affects SVV independently of the effect of driving pressure. We aimed to investigate the effect of driving pressure and PEEP on SVV under various preload conditions using beagle dogs as the animal model. We prepared three preload model, baseline, mild and moderate hemorrhage model. Mild and moderate hemorrhage models were created in 9 anesthetized, mechanically ventilated dogs by sequentially removing 10 mL/kg, and then an additional 10 mL/kg of blood, respectively. We measured cardiac output, stroke volume (SV), SVV, heart rate, central venous pressure, pulmonary capillary wedge pressure and the mean arterial pressure under varying ventilation settings. Peak inspiratory pressure (PIP) was incrementally increased by 4 cmH2 O, from 9 cmH2 O to 21 cmH2 O, under PEEP values of 4, 8, and 12 cmH2 O. The driving pressure did not significantly decrease SV under each preload condition and PEEP; however, significantly increased SVV. In contrast, the increased PEEP decreased SV and increased SVV under each preload condition and driving pressure, but these associations were not s...
Source: Clinical and Experimental Pharmacology and Physiology - Category: Drugs & Pharmacology Authors: Tags: Clin Exp Pharmacol Physiol Source Type: research