Transient elastography for assessment of fibrosis and steatosis of liver grafts from brain-death donors

Publication date: Available online 25 January 2020Source: Clinics and Research in Hepatology and GastroenterologyAuthor(s): Wen-Yi Liu, Jian-Hong Wang, Yuan Guo, Xin Wang, Xiao-Dong Wu, Chuan-Shen Xu, Yang Zhao, Yun-Jin ZangSummaryBackgroundAn objective and accurate evaluation of liver grafts is required to improve the prognosis of liver transplant recipients and to increase the number of available liver grafts.AimTo compare outcomes using FibroScan with that of pathology in liver grafts from brain-dead donors (DBD).MethodsLiver grafts from 52 DBD were examined using ultrasound (US), FibroScan before liver transplantation (LT). Blood tested before LT and a biopsy was performed pre- or intra-operation to determine pathology. The diagnostic accuracy of the FibroScan results was compared with the pathology results, which is the gold standard for evaluating liver grafts. The donors enrolled were grouped by the stage of liver fibrosis (F0-F4) and steatosis (S0-S3), based on Kleiner's scoring system of nonalcoholic fatty liver disease, respectively.ResultsThe liver stiffness (LS) value in group F1 was significantly increased compared with group F0 (8.74 ± 1.32 kPa and 5.93 ± 1.64 kPa, respectively, P 
Source: Clinics and Research in Hepatology and Gastroenterology - Category: Gastroenterology Source Type: research

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Conclusion: Our results indicate that FABP1 may play a role in the pathogenesis of NAFLD in patients with T2DM. PMID: 32038102 [PubMed - in process]
Source: International Journal of Medical Sciences - Category: Biomedical Science Tags: Int J Med Sci Source Type: research
Nonalcoholic fatty liver disease (NAFLD), defined as fat accumulation greater than 5% in hepatocytes, may progress to fibrosis or cirrhosis later in life. NAFLD prevalence in adolescents has increased significantly in direct relation with obesity prevalence. Fatty liver has become the most frequent indication for liver transplantation in adults. Objective: The aim of the study was to identify anthropometric variables during the first 10 years of life associated to the risk of developing NAFLD in adolescence. Methods: Longitudinal cohort study ’Growth and Obesity Chilean Cohort Study’ (GOCS) consisting of ...
Source: Journal of Pediatric Gastroenterology and Nutrition - Category: Gastroenterology Tags: Original Articles: Hepatology Source Type: research
Abstract Non-alcoholic fatty liver disease (NAFLD) is the most common cause of liver disease, the most common cause of chronic liver function augmentation and it will be the most common indication for liver transplantation in 2020. The prevalence of NAFLD has increased over time in line with the increase of obesity and type 2 diabetes. There is a discrepancy between the studies concerning the prevalence of NAFLD because of the different diagnostic methods used (ultrasound or magnetic resonance, fibroscan, controlled attenuation parameter (CAP), histology). Because of its high prevalence the impact of NAFLD in publ...
Source: Presse Medicale - Category: General Medicine Authors: Tags: Presse Med Source Type: research
CONCLUSIONS: The use of probiotics/synbiotics was associated with improvement in liver-specific markers of hepatic inflammation, LSM, and steatosis in persons with NAFLD. Although promising, given the heterogeneity in pooled analyses, additional well-designed RCTs are needed to define the efficacy of probiotics/synbiotics for treatment of NAFLD. This study was registered with PROSPERO as CRD42018091455. PMID: 31124558 [PubMed - as supplied by publisher]
Source: The American Journal of Clinical Nutrition - Category: Nutrition Authors: Tags: Am J Clin Nutr Source Type: research
Non-alcoholic fatty liver disease (NAFLD), a condition of extra fat buildup in the liver, is on the rise — it now affects roughly 20% to 40% of the US population. It usually doesn’t cause any symptoms, and is often first detected by accident when an imaging study (such as an abdominal ultrasound, CT scan, or MRI) is requested for another reason. A fatty liver may also be identified on an imaging test as a part of investigating abnormal liver blood tests. NAFLD is intimately related to conditions like diabetes and obesity. It’s also linked to an increased risk of cardiovascular disease. Understanding NAFLD...
Source: Harvard Health Blog - Category: Consumer Health News Authors: Tags: Digestive Disorders Health Source Type: blogs
Nonalcoholic fatty liver disease (NAFLD) is now the most prevalent liver disease in the world. It involves a spectrum of conditions from hepatic steatosis to nonalcoholic steatohepatitis and liver fibrosis, and is a major cause of cirrhosis and hepatocellular carcinoma. It is defined by presence of steatosis in 5% of hepatocytes or more in the absence of other causes of fatty liver. The metabolic syndrome is the major known risk factor for NAFLD. Dietary contributors such as high fructose intake and coffee consumption appear to increase and decrease the risk of disease respectively, but these links are unclear. Genetic ass...
Source: European Journal of Gastroenterology and Hepatology - Category: Gastroenterology Tags: Review Articles Source Type: research
Authors: Piñero F, Pages J, Marciano S, Fernández N, Silva J, Anders M, Zerega A, Ridruejo E, Ameigeiras B, D'Amico C, Gaite L, Bermúdez C, Cobos M, Rosales C, Romero G, McCormack L, Reggiardo V, Colombato L, Gadano A, Silva M Abstract AIM: To investigate any changing trends in the etiologies of hepatocellular carcinoma (HCC) in Argentina during the last years. METHODS: A longitudinal cohort study was conducted by 14 regional hospitals starting in 2009 through 2016. All adult patients with newly diagnosed HCC either with pathology or imaging criteria were included. Patients were classified ...
Source: World Journal of Hepatology - Category: Gastroenterology Tags: World J Hepatol Source Type: research
ConclusionRecently, cross-sectional imaging assessment of diffuse liver diseases has gained momentum due to its ability to provide both anatomical and functional assessments of normal and abnormal tissues. Various imaging techniques are being employed to assess diffuse liver diseases including magnetic resonance imaging (MRI), computed tomography (CT), and ultrasound (US). MRI has the ability to detect abnormal intracellular and molecular processes and tissue architecture. CT has a high spatial resolution, while US provides real-time imaging, is inexpensive, and readily available. We herein review current state-of-the-art ...
Source: Journal of Gastrointestinal Surgery - Category: Surgery Source Type: research
In conclusion, while the management of PHT in patients with ESLD is based on strong evidence, further data on the value of non‐invasive monitoring tools, as well as on medical and invasive treatment options in the post‐OLT setting are needed to improve management strategies in patients with recurrent PHT after liver transplantation. This article is protected by copyright. All rights reserved.
Source: Liver Transplantation - Category: Transplant Surgery Authors: Tags: Review Article Source Type: research
Publication date: May 2017 Source:Journal of the American College of Radiology, Volume 14, Issue 5, Supplement Author(s): Jeanne M. Horowitz, Ihab R. Kamel, Hina Arif-Tiwari, Sumeet K. Asrani, Nicole M. Hindman, Harmeet Kaur, Michelle M. McNamara, Richard B. Noto, Aliya Qayyum, Tasneem Lalani Because liver fibrosis can be treated, it is important to diagnose liver fibrosis noninvasively and monitor response to treatment. Although ultrasound (grayscale and Doppler) can diagnose cirrhosis, it does so unreliably using morphologic and sonographic features and cannot diagnose the earlier, treatable stages of hepatic fibrosis. ...
Source: Journal of the American College of Radiology - Category: Radiology Source Type: research
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