Prospective Randomized Study of Prophylactic Ciprofloxacin Versus Levofloxacin in Hematopoietic Stem Cell Transplant Patients: An Interim Report

Infection is a serious complication of hematopoietic stem cell transplantation (SCT). However, the optimum oral agent for antibacterial prophylaxis in SCT recipients remains uncertain. Different antibiotics might affect incidence of blood stream infections, resistance, Clostridium difficile, gut microbiome, GVHD and relapse. To explore this we started this first clinical trial of levofloxacin (Levo) versus ciprofloxacin (Cipro) at our center.Methods: This is a single center prospective randomized study.

Source: Biology of Blood and Marrow Transplantation - January 24, 2020 Category: Hematology Authors: Shatha Farhan, Georgiana Marusca, Michael Bazydlo, Klodiana Neme, Nancy Mikulandric, Josena Stephen, Neda Kortam, Ramesh Mayur, Danielle Pelland, Nada Zagar, Mary Ann Trapp, Elizabeth Henne, Scott Rohrer, Sarah Szymanski, Josephine Emole, Edward Peres, Na Tags: 491 Source Type: research