Mortality from HIV-associated meningitis in sub-Saharan Africa: a systematic review and meta-analysis.

CONCLUSIONS: Mortality rates from HIV-associated meningitis in SSA are very high under routine care conditions. Better strategies are needed to reduce mortality from HIV-associated meningitis in the region. PMID: 31957332 [PubMed - in process]
Source: Journal of the International AIDS Society - Category: Infectious Diseases Tags: J Int AIDS Soc Source Type: research

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By Margarite Nathe, Principal Editor/Writer, IntraHealth International Midwives and nurses —like Sellyvine (left) at the women's hospital in Nakuru, Kenya —make up 50% of the health workforce worldwide. They're in the spotlight during 2020 and will play a crucial role in whether their countries can achieve their most ambitious health targets by 2030. Photo by Georgina Goodwin for IntraHealth International.February 14, 2020Every year, we look at the top global health issues coming our way in the next 12 months. But global health is a long game and it’s a brand-new decade, so this year, we’re look...
Source: IntraHealth International - Category: International Medicine & Public Health Authors: Tags: Family Planning & Reproductive Health HIV AIDS Infectious Diseases Maternal, Newborn, Child Health Mental Health Noncommunicable Diseases Digital Health Policy Advocacy Gender Equality Nursing Midwifery Youth Midwives N Source Type: news
Discussion: Neuro-ophthalmic consequences of HIV are important to recognize as it is critical to identify underlying neoplastic or infectious diseases which could be amenable to treatment. PMID: 31961200 [PubMed - as supplied by publisher]
Source: Ocular Immunology and Inflammation - Category: Allergy & Immunology Tags: Ocul Immunol Inflamm Source Type: research
AbstractPurpose of ReviewCryptococcal meningitis is one of the most seriously opportunistic infections in people living with HIV. We evaluated clinical and laboratorial features (minimum inhibitory concentrations for fluconazole, initial fungal burden in cerebrospinal fluid) and risk factors associated with in-hospital mortality.Recent FindingsThere is no good evidence for the use of minimum inhibitory concentrations for fluconazole in routine practice for the management of cryptococcosis patients. Counting yeast cells at cerebrospinal fluid can predict positive culture by not death.SummaryData from 46 cryptococcal meningi...
Source: Current Fungal Infection Reports - Category: Infectious Diseases Source Type: research
Conclusion: PSQ helps detecting MTB complex directly fromCSF even with negative Xpert. Early diagnosis, detection of resistance aids in administering appropriate treatment early and decrease mortality, long term disability. PSQ shows promising results in diagnosing, early detection of resistance in CNS TB. Though correlation with phenotypic DST recommended &further research warranted.
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Tuberculosis Source Type: research
ConclusionThe countries in this region needs to work hard to reduce this burden. This requires huge investment especially the finance and human resource development.
Source: International Journal of Africa Nursing Sciences - Category: African Health Source Type: research
We describe a case of a diabetic and morbidly obese, but otherwise healthy man, who developed bacteremia and perinephric abscess due to Lactobacillus species.
Source: Infectious Diseases in Clinical Practice - Category: Infectious Diseases Tags: Case Reports Source Type: research
Condition:   Tuberculous Meningitis Interventions:   Drug: Aspirin;   Drug: Placebo of aspirin;   Drug: WHO TBM treatment;   Drug: Intensified TBM treatment Sponsors:   French National Institute for Health and Medical Research-French National Agency for Research on AIDS and Viral Hepatitis (Inserm-ANRS);   European Union;   European and Developing Countries Clinical Trials Partnership (EDCTP) Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
CONCLUSIONS: Cryptococcal ocular involvement in AIDS patients has been occasionally proved among the cases already reported. Thus, the post mortem exam is still pivotal to improve the quality of the clinical diagnosis, especially in limited-resource settings. PMID: 31676212 [PubMed - as supplied by publisher]
Source: Revista Iberoamericana de Micologia - Category: Biology Authors: Tags: Rev Iberoam Micol Source Type: research
Authors: Trovero AC, Mazza M, Rogé A, Rivas MC, Bordagorría X, Bruno S, Davel G Abstract Cryptococcosis is a fungal disease affecting more than one million people per year worldwide. Its main etiological agents are Cryptococcus neoformans species complex and Cryptococcus gattii species complex. Cryptococcal meningitis (CM) is considered an AIDS-defining condition. Rapid diagnosis by cryptococcal antigen assays, either the latex agglutination test (LA) or the lateral flow assay, is key to decreasing mortality due to cryptococcal disease. The aim of the study was to develop a latex agglutination reagent...
Source: Revista Argentina de Microbiologia - Category: Microbiology Tags: Rev Argent Microbiol Source Type: research
We describe demographic, socioeconomic and clinical characteristics of patients randomized to the same-day initiation arm for both studies. RESULTS AND DISCUSSION: A total of 240 and 296 participants were enrolled in Kenya and South Africa. The majority were female (59% and 64% respectively), with a median age of 35 years. In both countries, most subjects were newly diagnosed with HIV on the day of enrolment (62%, 55%), believed they already had adequate knowledge to begin ART (78%, 68%), and preferred to start ART immediately (same-day) (98% in both countries). About 40% of all patients had at least one symptom r...
Source: Journal of the International AIDS Society - Category: Infectious Diseases Tags: J Int AIDS Soc Source Type: research
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