Crystal violet structural analogues identified by in < i > silico < /i > drug repositioning present anti- < i > Trypanosoma cruzi < /i > activity through inhibition of proline transporter TcAAAP069

Conclusions/SignificanceLoratadine, cyproheptadine and clofazimine inhibit TcAAAP069 proline transporter and also present trypanocidal effect against allT.cruzi life stages in strains from three different DTUs. These CV structural analogues could be a starting point to design therapeutic alternatives to treat Chagas disease by finding new indications for old drugs. This approach, called drug repurposing is a recommended strategy by the World Health Organization to treat neglected diseases, like Chagas disease, and combination therapy may improve the possibility of success of repositioned drugs.

Source: PLoS Neglected Tropical Diseases - January 20, 2020 Category: Tropical Medicine Authors: Melisa Say é Source Type: research