Pathological roles of MRP14 in anemia and splenomegaly during experimental visceral leishmaniasis

In this study, to examine the pathological involvement of MRP14 during cutaneous and visceral leishmaniasis, wild-type (WT) and MRP14 knockout (MRP14KO) mice were infected withLeishmania major andL.donovani. Increase in the number of MRP14+ cells at the infection sites in wild-type mice was commonly found in the skin duringL.major infection as well as the spleen and liver duringL.donovani infection. In contrast, the influence of MRP14 to the pathology seemed different between the two infections. MRP14 depletion exacerbated the lesion development and ulcer formation inL.major infection. On the other hand, the depletion improved anemia and splenomegaly but not leukopenia or hepatomegaly at 24 weeks ofL.donovani infection. These results suggest that, distinct from its protective role in CL, MRP14 is involved in exacerbation of some symptoms during VL.
Source: PLoS Neglected Tropical Diseases - Category: Tropical Medicine Authors: Source Type: research