LCK inhibitor attenuates atherosclerosis in ApoE −/− mice via regulating T cell differentiation and reverse cholesterol transport

Lots of studies demonstrated that CD4+ T cells regulate the development of atherosclerosis (AS). Previously, we reported that LCK, a key molecule in activation of T cell receptor (TCR) signalling and T cells, adversely affects reverse cholesterol transport (RCT), which ameliorates AS in vitro. To investigate the effect of LCK on AS in vivo, we injected the LCK inhibitor, PP2, into ApoE −/− mice fed a chow diet or a high-fat diet (HFD). Although, AS plaques were not affected by PP2 in chow diet-fed mice, PP2 significantly reduced the lesion percentage and necrotic core areas in HFD-fed mice.

Source: Journal of Molecular and Cellular Cardiology - January 19, 2020 Category: Cytology Authors: Jichen Liu, Zhongzhou Guo, Yanan Zhang, Tongwei Wu, Yusheng Ma, Wenyan Lai, Zhigang Guo Source Type: research