GSE121750 Functional heterogeneity within the developing zebrafish epicardium

In this study, we investigated epicardial heterogeneity and the functional diversity of discrete epicardial subpopulations in the developing zebrafish heart. Single-cell RNA-sequencing uncovered three epicardial subpopulations with specific genetic programmes and distinctive spatial distribution within the developing heart. Perturbation of unique gene signatures uncovered distinct functions associated with each subpopulation and established novel epicardial roles in cell adhesion, migration, and chemotaxis as a mechanism for recruitment of leukocytes into the heart. This work elucidates the mutual spatiotemporal relationships between different epicardial subpopulations and assigns unique function to each during cardiac development. Understanding which mechanisms cells employ to establish a functional epicardium and to communicate with other cardiovascular cell types during development will bring us closer to repairing cellular relationships that are disrupted during cardiovascular disease.
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Danio rerio Source Type: research

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CONCLUSIONS: Tension-free mesh repair is associated with low morbidity and low recurrence rates in PD patients. Timely management and close collaboration with renal physicians are essential to continue PD after repair. PMID: 32063146 [PubMed - in process]
Source: Peritoneal Dialysis International - Category: Urology & Nephrology Tags: Perit Dial Int Source Type: research
GENERAL PURPOSE To review the nutrition-related recommendations presented in the 2019 European Pressure Ulcer Advisory Panel, National Pressure Injury Advisory Panel, and Pan Pacific Pressure Injury Alliance Prevention and Treatment of Pressure Ulcers/Injuries: Clinical Practice Guideline with further discussion of nutrition for pressure injury management in the context of the recommendations. TARGET AUDIENCE This continuing education activity is intended for physicians, physician assistants, nurse practitioners, and nurses with an interest in skin and wound care. LEARNING OBJECTIVES/OUTCOMES After participating in...
Source: Advances in Skin and Wound Care - Category: Dermatology Tags: CLINICAL MANAGEMENT EXTRA Source Type: research
Conclusions: This study is the first to characterize the coding transcriptome of PEG-fused PNAs, and identifies possible links between alterations of the extracellular matrix and suppression of the allorejection response. The results establish a molecular-basis to understand mechanisms underlying PEG-mediated immunosuppression.
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Rattus norvegicus Source Type: research
Publication date: Available online 18 February 2020Source: Stem Cell ResearchAuthor(s): Alan T.L. Lam, Shaul Reuveny, Steve Kah-Weng OhAbstractArticular cartilage defects are one of the major challenges in orthopedic and trauma surgery. However, the poor ability of cartilage to self-repair has motivated efforts to engineer replacement tissues, and human mesenchymal stem cells (MSC), which have an extensive proliferation potential and can undergo chondrogenesis, have emerged as a promising cell source. In this review, we attempt to provide a brief overview of MSC isolation, characterization, current manufacturing platforms ...
Source: Stem Cell Research - Category: Stem Cells Source Type: research
Publication date: 18 February 2020Source: Cell Reports, Volume 30, Issue 7Author(s): Mu-Yan Cai, Connor E. Dunn, Wenxu Chen, Bose S. Kochupurakkal, Huy Nguyen, Lisa A. Moreau, Geoffrey I. Shapiro, Kalindi Parmar, David Kozono, Alan D. D’AndreaSummaryCells deficient in ataxia telangiectasia mutated (ATM) are hypersensitive to ionizing radiation and other anti-cancer agents that induce double-strand DNA breaks. ATM inhibitors may therefore sensitize cancer cells to these agents. Some cancers may also have underlying genetic defects predisposing them to an ATM inhibitor monotherapy response. We have conducted a genome-w...
Source: Cell Reports - Category: Cytology Source Type: research
ConclusionOur study findings clarify the differences between parietal bone and scapula repair and suggest that the bone repair process differs among ossification patterns.
Source: Journal of Oral Biosciences - Category: Biomedical Science Source Type: research
ConclusionDe-hUC-MSCs reprogramming of endogenous hSDF-1α expression may mediate the hSDF-1α/CXCR4/PI3K/Akt pathway involved in nerve repair in HIBD rats.
Source: Genes and Diseases - Category: Genetics & Stem Cells Source Type: research
A 92-year-old woman with a foreign body perforation of the esophagus underwent esophageal repair and esophageal stent placement. A computed tomography (CT) scan of the chest performed for worsening leukocytosis demonstrated an enlarging air-containing mediastinal collection despite a surgically placed mediastinal drain; interventional radiology was consulted. The 3-day-old anteriorly placed drain had a long infracardiac course, and drain exchange was believed to be too high risk for loss of access.
Source: Journal of Vascular and Interventional Radiology : JVIR - Category: Radiology Authors: Tags: Extreme IR Source Type: research
Publication date: Available online 17 February 2020Source: Journal of Membrane ScienceAuthor(s): Yun Li, Baoquan ZhangAbstractThe elimination of defects in zeolite membranes is of vital importance to achieve superior separation performances. A facile and versatile strategy was proposed to repair defects in zeolite membranes via vacuum-wiping deposition (VWD) with spherical polyelectrolyte complex (PEC) nanoparticles as the filler, realizing defects reparation and surface hydrophilic modification of zeolite beta membranes simultaneously. The repaired zeolite beta membrane was applied to the separation of methanol/methyl ter...
Source: Journal of Membrane Science - Category: Materials Science Source Type: research
Contributors : Shiri Gur-Cohen ; Hanseul Yang ; Elaine FuchsSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusTissues rely on stem cells (SCs) for homeostasis and wound-repair. SCs reside in specialized microenvironments (niches) whose complexities and roles in orchestrating tissue growth are still unfolding. Here, we identify lymphatic capillaries as critical SC niche components. In skin, lymphatics form intimate networks around the SCs of each hair follicle (HF) during their non-regenerative phase, and remodel upon regeneration. Seeking understanding, we unravel a secretome switch wit...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
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