Trimethylamine-N-Oxide Promotes Vascular Calcification Through Activation of NLRP3 (Nucleotide-Binding Domain, Leucine-Rich-Containing Family, Pyrin Domain-Containing-3) Inflammasome and NF- κB (Nuclear Factor κB) Signals.

CONCLUSIONS: This study for the first time demonstrates that TMAO promotes vascular calcification through activation of NLRP3 inflammasome and NF-κB signals, suggesting the potential link between gut microbial metabolism and vascular calcification. Reducing the levels of TMAO could become a potential treatment strategy for vascular calcification in chronic kidney disease. PMID: 31941382 [PubMed - as supplied by publisher]
Source: Arteriosclerosis, Thrombosis and Vascular Biology - Category: Cardiology Authors: Tags: Arterioscler Thromb Vasc Biol Source Type: research

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Source: Journal of Renal Nutrition - Category: Urology & Nephrology Source Type: research
Source: Journal of Renal Nutrition - Category: Urology & Nephrology Source Type: research
Source: Journal of Renal Nutrition - Category: Urology & Nephrology Source Type: research
Source: Journal of Renal Nutrition - Category: Urology & Nephrology Source Type: research
Source: Journal of Renal Nutrition - Category: Urology & Nephrology Source Type: research
Source: Journal of Renal Nutrition - Category: Urology & Nephrology Source Type: research
Source: Journal of Renal Nutrition - Category: Urology & Nephrology Source Type: research
Source: Journal of Renal Nutrition - Category: Urology & Nephrology Source Type: research
Source: Journal of Renal Nutrition - Category: Urology & Nephrology Source Type: research
Conclusion: These updated French guidelines will contribute to increase the level of urological care for the diagnosis and treatment for NMIBC and MIBC. PMID: 32093463 [PubMed - in process]
Source: Progres en Urologie - Category: Urology & Nephrology Tags: Prog Urol Source Type: research
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