IL-17A in Psoriasis and Beyond: Cardiovascular and Metabolic Implications

In conclusion, clinical recommendations for patients with moderate to severe psoriasis based on the current available data are given.
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research

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Authors: Dalmády S, Kemény L, Antal M, Gyulai R Abstract Introduction: Psoriasis is a chronic autoimmune skin disease with strong genetic background and environmental triggers. Patients with psoriasis and psoriatic arthritis are at greater risk of developing other chronic and potentially severe comorbidities, such as psoriatic arthritis, hyperlipidemia, type 2 diabetes mellitus, obesity, metabolic syndrome, cardiovascular diseases or depression. Recently, accumulating epidemiologic, genetic and pathogenetic evidence indicates that psoriasis is also associated with periodontitis, a chronic progressive ...
Source: Expert Review of Clinical Immunology - Category: Allergy & Immunology Tags: Expert Rev Clin Immunol Source Type: research
ConclusionsSecukinumab appears to be cost effective compared with other DMARDs for the treatment of active PsA in biologic-na ïve and biologic-experienced populations in Germany.
Source: Applied Health Economics and Health Policy - Category: Health Management Source Type: research
Abstract This review is a simple guide to the deeper meaning of the association of a disease with a particular HLA allele. We will first review some principles of the function of the adaptive immune system, and some basic notions of autoimmune disease. In this, we will focus on the tripartite unity of the Human Leukocyte Antigen (HLA)-molecule, the peptide, and the T cell receptor that recognizes the complex of peptide and HLA molecule, placing emphasis on the function of the T cell receptor. We will also touch on the evolutionary forces shaping our adaptive immune system. Then we will apply this background to som...
Source: Swiss Medical Weekly - Category: General Medicine Authors: Tags: Swiss Med Wkly Source Type: research
CONCLUSION: (1) Both immune disorder and bone metabolic dysregulation could be the shared mechanism in the development of PsA, PV, RA, and GA. (2) Immune dysfunction is involved in GA. Our study may shed new light on the diagnosis and treatment strategy of these autoimmune diseases and GA, which warrants further studies. PMID: 31465725 [PubMed - in process]
Source: Discovery Medicine - Category: Research Tags: Discov Med Source Type: research
Introduction: Psoriasis and psoriatic arthritis (PsA) are chronic inflammatory diseases of unclear etiology. There is evidence, that genetic, immunologic, and environmental factors contribute to its pathology. Autoimmune oophoritis has been proposed as one of the possible etiologies of diminished ovarian reserve. Pro-inflammatory cytokine - tumor necrosis factor alpha (TNF α) is implicated in the pathogenesis of oophoritis and psoriasis. Certolizumab is an anti-TNFα monoclonal antibody studied now in the treatment of psoriasis.
Source: Maturitas - Category: Primary Care Authors: Tags: LBP01 Source Type: research
Conclusions: PET has the advantage of being able to detect degenerative joint changes at a molecular level even before the structural changes have taken place. Hence, it has superiority over other conventional imaging modalities to detect arthritis in the early stages as well as investigate multiple joints in a single scan. As the resolution of PET is relatively low, combining PET with CT provides structural information to better assess the joint. Quantifying disease activity has the benefit of surveilling disease activity over the course of time and monitoring treatment response, remission and relapse of the disease.
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Educational Exhibit Posters Source Type: research
Conclusion Although GWAS contributed insight into the utility of the genotype biomarker to treatment selection, adequately powered prospective studies will be required before clinical application of pharmacogenomics can become a reality. Genotype and phenotype assessment should be facilitated by the availability of detailed molecular analyses and data integration. Careful assessment of prospective GWAS data is essential to integrate findings into the clinical decision-making process, and thereby optimizing the treatment of patients with psoriasis in the future. Author Contributions BY, NG, and WY performed the project. ...
Source: Frontiers in Genetics - Category: Genetics & Stem Cells Source Type: research
Discussion Suppressor of cytokine signaling 1 is an essential molecule for maintaining immune homeostasis and subverting inflammation. Disorders arising from excess inflammation or SOCS1 deficiency can be potentially treated with SOCS1 mimetics (Ahmed et al., 2015). While SOCS1 has promising potential in many disorders, it should be noted that new targets and actions of SOCS1 are still being discovered and not all the effects of this protein are beneficial in autoimmune diseases and cancer. For instance, SOCS1 degrades IRS1 and IRS2, required for insulin signaling, via the SOCS Box domain, thus, limiting its potential in ...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
In this study, we hypothesized that appropriate epigenomic elements (H3K27ac marks for active enhancers) can guide us to reveal valuable information about the loci with suggestive evidence of association. Our aim is to investigate these loci and explore how they may lead to the development of PsA. We evaluated this potential by investigating the genes connected with these loci from the perspective of pharmacogenomics and gene expression. We illustrated that markers with suggestive evidence of association outside the MHC region are enriched in H3K27ac marks for osteoblast and chondrogenic differentiated cells; using pharmac...
Source: Frontiers in Genetics - Category: Genetics & Stem Cells Source Type: research
We presented a new statistic T to use large public database as reference to reduce concern of potential population stratification. And the new statistic proposed here is effective to discover novel genome-wide significant loci with both small and large sample sizes. Author Contributions YW conceived the idea and developed the software. YL, MH, and XL contributed data analysis, generating tables and figures, and manuscript writing. YW, YL, MH, XL, YS, and LJ contributed the theoretical analysis and manuscript revision. MX helped support the GWAS datasets. YW, YL, MH, XL, MZ, JW, and MX contributed to scientific discussion...
Source: Frontiers in Genetics - Category: Genetics & Stem Cells Source Type: research
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