Inactivation of TRP53, PTEN, RB1 and/or CDH1 in the ovarian surface epithelium induces ovarian cancer transformation and metastasis.

Inactivation of TRP53, PTEN, RB1 and/or CDH1 in the ovarian surface epithelium induces ovarian cancer transformation and metastasis. Biol Reprod. 2020 Jan 13;: Authors: Shi M, Whorton AE, Sekulovski N, Paquet M, MacLean JA, Song Y, Van Dyke T, Hayashi K Abstract Ovarian cancer (OvCa) remains the most common cause of death from gynecological malignancies. Genetically engineered mouse models have been used to study initiation, origin, progression and/or mechanisms of OvCa. Based on the clinical features of OvCa, we examined a quadruple combination of pathway perturbations including PTEN, TRP53, RB1, and/or CDH1. To characterize the cancer-promoting events in the ovarian surface epithelium (OSE), Amhr2cre/+ mice were used to ablate floxed alleles of Pten, Trp53 and Cdh1, which were crossed with TgK19GT121 mice to inactivate RB1 in KRT19 expressing cells. Inactivation of PTEN, TRP53 and RB1 with or without CDH1 developed Type I low-grade OvCa with enlarged serous papillary carcinomas and some high-grade serous carcinomas (HGSC) at older mice. Initiation of epithelial hyperplasia and micropapillary carcinoma started earlier at 1-mo in the triple mutations of Trp53, Pten and Rb1 mice as compared to 2-mo in quadruple mutations of Trp53, Pten, Rb1 and Cdh1 mice, whereas both genotypes eventually developed enlarged proliferating tumors that invaded into the ovary at 3~4-mo. Mice with triple and quadruple mutations developed HGSC and/or metastatic tumors which dis...
Source: Biology of Reproduction - Category: Reproduction Medicine Authors: Tags: Biol Reprod Source Type: research

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Conclusions: Docetaxel and epirubicin neoadjuvant chemotherapy showed a good response in locally advanced breast cancer. Pretreatment Ki-67 and change of Ki-67 may play a role as predictive factor for response to neoadjuvant chemotherapy. PMID: 32069523 [PubMed - as supplied by publisher]
Source: The Korean Journal of Internal Medicine - Category: Internal Medicine Authors: Tags: Korean J Intern Med Source Type: research
In conclusion, as the dose rates at a 1-m distance from patients upon release were
Source: Radiation Physics and Chemistry - Category: Physics Source Type: research
In this study, we proposed a Graph Convolutional Network (GCN) model to predict synergistic drug combinations in particular cancer cell lines. Specifically, the GCN method used a convolutional neural network model to do heterogeneous graph embedding, and thus solved a link prediction task. The graph in this study was a multimodal graph, which was constructed by integrating the drug-drug combination, drug-protein interaction, and protein–protein interaction networks. We found that the GCN model was able to correctly predict cell line-specific synergistic drug combinations from a large heterogonous network. The ma...
Source: Computational and Structural Biotechnology Journal - Category: Biotechnology Source Type: research
Publication date: Available online 19 February 2020Source: Biosensors and BioelectronicsAuthor(s): Amin Hassanzadeh-Barforoushi, Majid Ebrahimi Warkiani, David Gallego-Ortega, Guozhen Liu, Tracie BarberAbstractCancer cells continuously secrete inflammatory biomolecules which play significant roles in disease progression and tumor metastasis toward secondary sites. Despite recent efforts to capture cancer cells' intercellular secretion heterogeneity using microfluidics, the challenges in operation of these systems as well as the complexity of designing a biosensing assay for long-term and real-time measurement of single cel...
Source: Biosensors and Bioelectronics - Category: Biotechnology Source Type: research
Mucoepidermoid Carcinoma Showing "Finger-in-glove" Sign on PET-CT. Intern Med. 2020 Feb 19;: Authors: Shigemi S, Uchimura K, Tanaka F, Yatera K PMID: 32074577 [PubMed - as supplied by publisher]
Source: Internal Medicine - Category: Internal Medicine Tags: Intern Med Source Type: research
Authors: Iwamoto M, Gotoda T, Noda Y, Esaki M, Moriyama M, Yoshida N, Takayama T, Kobayashi H, Masuda S Abstract As gastric neuroendocrine carcinoma (NEC) is a rapidly growing cancer, most cases are diagnosed at advanced stages. We herein report a 74-year-old woman with an early-stage gastric NEC whose history included endoscopic submucosal dissection treatment for three early-stage gastric cancer lesions five years prior to the current presentation. We also describe the changes observed over time. An endoscopic examination during follow-up revealed an NEC (measuring 6 mm) in the gastric vestibule, for which distal...
Source: Internal Medicine - Category: Internal Medicine Tags: Intern Med Source Type: research
Conclusion Based on the RR, Conv R, and symptom palliation ability, mFOLFOXIRI+α was suggested to be a viable candidate for first-line treatment for patients with ARCC, especially those with a high tumor burden. PMID: 32074573 [PubMed - as supplied by publisher]
Source: Internal Medicine - Category: Internal Medicine Tags: Intern Med Source Type: research
Publication date: March 2020Source: Advances in Medical Sciences, Volume 65, Issue 1Author(s): Javad Masoumi, Abdollah Jafarzadeh, Hossein Khorramdelazad, Morteza Abbasloui, Jalal Abdolalizadeh, Najmeh JamaliAbstractApelin is an endogenous peptide, which is expressed in a vast board of organs such as the brain, placenta, heart, lungs, kidneys, pancreas, testis, prostate and adipose tissues. The apelin receptor, called angiotensin-like-receptor 1 (APJ), is also expressed in the brain, spleen, placenta, heart, liver, intestine, prostate, thymus, testis, ovary, lungs, kidneys, stomach, and adipose tissue. The apelin/APJ axis ...
Source: Advances in Medical Sciences - Category: Biomedical Science Source Type: research
Columbia Sportswear CEO Tim Boyle and his wife Mary have given $10 million to Oregon Health&Science University to support the joint center for biomedical data science, OHSU announced. The Boyles gift will go to the OHSU-University of Oregon Center for Biomedical Data Science, a collaboration that is using “big data” to fight cancer and other diseases. The donation will be used to recruit a director to oversee both sites and an associate directors and three-to-five faculty m embers who specialize…
Source: bizjournals.com Health Care:Biotechnology headlines - Category: Biotechnology Authors: Source Type: news
AbstractColorectal cancer (CRC) refers to a deadly carcinoma following potent invasiveness and metastasis in advanced stage. Unfortunately, existing anti ‐CRC medicine is insufficient for chemotherapy in addition to adverse effects. Consequently, the candidate natural ingredient for treating CRC needs to be further developed. Our previous experiments report that genistein exerts beneficial effects to inhibit CRC cells via an antiproliferative mecha nism. Based on the metastatic characteristics of staging CRC, anti‐invasive and antimetastatic pharmacological activities using genistein remain uninvestigated. The scientif...
Source: BioFactors - Category: Biochemistry Authors: Tags: Research Communication Source Type: research
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