Pitolisant for Daytime Sleepiness in Obstructive Sleep Apnea Patients Refusing CPAP: A Randomized Trial.

CONCLUSIONS: Pitolisant significantly reduced self-reported daytime sleepiness, fatigue and improved patient-reported outcomes and physician disease severity assessment in sleepy patients with obstructive sleep apnea refusing or non-adherent to continuous positive airway pressure. Clinical trial registration available at www.clinicaltrials.gov, ID: NCT01072968. PMID: 31917607 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/31917607?dopt=Abstract

Source: American Journal of Respiratory and Critical Care Medicine - January 8, 2020 Category: Respiratory Medicine Authors: Dauvilliers Y, Verbraecken J, Partinen M, Hedner J, Saaresranta T, Georgiev O, Tiholov R, Lecomte I, Tamisier R, Lévy P, Scart-Gres C, Lecomte JM, Schwartz JC, Pépin JL, HAROSA II study group. Tags: Am J Respir Crit Care Med Source Type: research