Role of Prostaglandins in Multiple Sclerosis.

Role of Prostaglandins in Multiple Sclerosis. Curr Pharm Des. 2020 Jan 07;: Authors: Gulla S, Lomada D, Anusha L, Reddanna P, Reddy MC Abstract Multiple sclerosis (MS) is an autoimmune demyelinating disorder with chronic inflammation in central nervous system, manifested by both physical and cognitive disability. Neuroinflammation and neurodegeneration are the phenomena that appear in the central nervous system associated with various neurodegenerative disorders including MS, Alzheimer's diseases, amyotrophic lateral sclerosis and Parkinson's disease. Prostaglandins are one of the major mediators of inflammation, that exhibit the important function in enhancing neuroinflammatory and neuro degenerative processes. These mediators would help to understand the pathophysiology of MS. As the combination of antagonists or agonists of prostaglandins receptors could be beneficial during the treatment of MS. The present review focuses on the role played by different prostaglandins and the enzymes which produced them in the etiopathogenesis of MS. PMID: 31914903 [PubMed - as supplied by publisher]
Source: Current Pharmaceutical Design - Category: Drugs & Pharmacology Authors: Tags: Curr Pharm Des Source Type: research

Related Links:

Publication date: Available online 20 February 2020Source: MicronAuthor(s): Jessica R. Morrice, Cheryl Y. Gregory-Evans, Christopher A. ShawAbstractMany different types of pathologies can arise in the central nervous system (CNS), such as neurodegeneration. The incidence of neurodegenerative diseases continues to increase, yet the pathogenesis underlying most neurodegenerative diseases, notably in amyotrophic lateral sclerosis (ALS), remains elusive. Neuronal support cells, or glia, are known to play a crucial role in ALS. Microglia are the resident immune cells of the CNS and also have neurotrophic support functions. Thes...
Source: Micron - Category: Biology Source Type: research
Publication date: Available online 19 February 2020Source: Life SciencesAuthor(s): Liu Yang, Xinyan Han, Jinfeng Yuan, Faping Xing, Zhixing Hu, Fei Huang, Hui Wu, Hailian Shi, Ting Zhang, Xiaojun WuAbstractAimsDendritic cells (DCs) actively participate in the pathogenesis of multiple sclerosis (MS), an autoimmune disease. Astragaloside IV (ASI), an active monomer isolated from the Chinese medicine Astragalus membranaceus, has a wide range of pharmacological effects. We aimed to elucidate the effects of ASI on the development of DCs in the early stage of MS/EAE.Main methodsThe mice were administered with ASI (20 mg/kg) da...
Source: Life Sciences - Category: Biology Source Type: research
Publication date: Available online 20 February 2020Source: Journal of Electroanalytical ChemistryAuthor(s): Ya Ma, Qiong Hu, Cheng Liu, Lishi WangAbstractIn this manuscript, a nanospherical conjugated microporous polymer (CMP) was synthesized. This material together with graphene nanosheets (GS) was used as electrode modification materials to construct a molecularly imprinted electrochemical sensor for high sensitivity detection of α-Synuclein (α-Syn). The MIP sensor was synthesized by electropolymerization pyrrole and characterized by scanning electron microscopy (SEM), cyclic voltammetry (CV) and differential...
Source: Journal of Electroanalytical Chemistry - Category: Chemistry Source Type: research
Publication date: March 2020Source: The Lancet Global Health, Volume 8, Issue 3Author(s): Charbel El Bcheraoui, Honoré Mimche, Yodé Miangotar, Varsha Sarah Krish, Faye Ziegeweid, Kris J Krohn, Martin Herbas Ekat, Jobert Richie Nansseu, Zacharie Tsala Dimbuene, Helen Elizabeth Olsen, Roger C K Tine, Christopher M Odell, Christopher E Troeger, Nicholas J Kassebaum, Tamer Farag, Simon I Hay, Ali H MokdadSummaryBackgroundPeer-reviewed literature on health is almost exclusively published in English, limiting the uptake of research for decision making in francophone African countries. We used results from the Globa...
Source: The Lancet Global Health - Category: International Medicine & Public Health Source Type: research
Publication date: March 2020Source: The Lancet Global Health, Volume 8, Issue 3Author(s): Anne Roca, Dominic Haslam OBE, Emma Jolley, Anna Ruddock, Elena Schmidt
Source: The Lancet Global Health - Category: International Medicine & Public Health Source Type: research
BACKGROUND: There is a dearth of reliable data on sexual assault prevalence amongst people with learning disabilities. This work aims to identify the prevalence of learning disabilities amongst adult clients attending Saint Marys Sexual Assault Referral Ce...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Economics of Injury and Safety, PTSD, Injury Outcomes Source Type: news
BACKGROUND: Nocturnal hypokinesia commonly affects Parkinson's disease (PD) patients, manifesting primarily as an impaired ability to turn in bed and sleeping in specific positions, such as prone that potentially poses the risk of positional asphyxia. ...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Elder Adults Source Type: news
Among Americans aged 65 years and older, falls are the leading cause of injury death and disability, and finding effective methods to prevent older adult falls has become a public health priority. While research has identified effective interventions deliv...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Elder Adults Source Type: news
Conditions:   Dystonia Disorder;   Parkinson Disease Interventions:   Drug: Botulinum toxin type A;   Drug: Placebo Sponsors:   University of Calgary;   Allergan Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Condition:   Intellectual Disability Intervention:   Behavioral: Intervention with active video games Sponsors:   Hong Kong Baptist University;   Research Grants Council (RGC) of Hong Kong Completed
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
More News: ALS | Alzheimer's | Autoimmune Disease | Brain | Disability | Drugs & Pharmacology | Multiple Sclerosis | Neurology | Parkinson's Disease