The epidemiology of headaches among patients with epilepsy: a systematic review and meta-analysis

ConclusionThe pooled estimated prevalence of headache among patients with epilepsy was considerably high (48.4%). Screening and appropriate management of headaches among patients with epilepsy are warranted.
Source: The Journal of Headache and Pain - Category: Neurology Source Type: research

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Publication date: April 2020Source: Research in Developmental Disabilities, Volume 99Author(s):
Source: Research in Developmental Disabilities - Category: Disability Source Type: research
Publication date: May 2020Source: Research in Developmental Disabilities, Volume 100Author(s): Marc Woodbury-Smith
Source: Research in Developmental Disabilities - Category: Disability Source Type: research
Conclusion: Our results indicate similar prevalence rates of comorbid psychiatric symptoms to studies carried out in the Middle East and North Africa (MENA) region and relatively high attendance and referral rates to psychiatric services.Implications: The results shed light on the clinical profile of patients in this region and support the need for integrated collaborative medical services. Moreover, findings have important implications for health care policies pertaining to resource distribution and funding.IntroductionMedical care has traditionally been dominated by a separation between disciplines catering to physiologi...
Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research
Conclusions The Cochrane reviews do not provide clear conclusions regarding the effectiveness of TMS and tDCS against adult chronic pain, although small benefits appear to have been observed. However, the authors point out many biases and important heterogeneities of these studies (30). At the moment, it is not possible to establish useful guidelines on the use of TMS and tDCS in the treatment of pediatric migraine and, in general, for pediatric pain treatment. However, adult studies as well as preliminary pediatric reports show that the application of these techniques is safe, with few side effects, potentially low cost...
Source: Frontiers in Neurology - Category: Neurology Source Type: research
Conclusion and Perspectives Since their cloning 20 years ago, the physiological importance of TREK-1 channels has continued to grow (Figure 3). Today, TREK-1 channels have been shown to be important and their presence is essential in a number of physiopathological processes. Their involvement in these different processes demonstrate the necessity to design pharmacological modulators, activators or inhibitors, of these channels to correct any TREK-1-related dysfunctions. Despites a number of studies and many molecule screenings, only few putative new drugs were identified. The activators belonging to the ML and BL series ...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
Conclusions: Pre-injury psychiatric and pre-injury headache/migraine symptoms are risk factors for worse functional and post-concussive outcomes at 3- and 6-months post-mTBI. mTBI patients presenting to acute care should be evaluated for psychiatric and headache/migraine history, with lower thresholds for providing TBI education/resources, surveillance, and follow-up/referrals. Clinical Trial Registration: www.ClinicalTrials.gov, identifier NCT01565551. Introduction Traumatic brain injury (TBI) remains a significant cause of morbidity and mortality worldwide. In 2013 ~2.8 million TBI cases were recorded annually i...
Source: Frontiers in Neurology - Category: Neurology Source Type: research
This study aims at investigating the still poorly clear pathogenesis of migraine and the potential role of anti-CGRP mAbs in the scenario of prophylaxis of migraine. Introduction: Migraine Clinic Migraine consists in unilateral headache accompanied by a cluster of other sensory, autonomic and cognitive symptoms and it has been identified by the global burden of disease (GBD) study 2016 as the sixth most prevalent disorder and one of the main causes of disability all over the world, often occuring in working age and in young adult and middle-aged women (Collaborators, 2018). Hence, migraine represents a very serious...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
Summary ObjectiveLow‐cost evidence‐based tools are needed to facilitate the early identification of patients with possible psychogenic nonepileptic seizures (PNES). Prior to accurate diagnosis, patients with PNES do not receive interventions that address the cause of their seizures and therefore incur high medical costs and disability due to an uncontrolled seizure disorder. Both seizures and comorbidities may contribute to this high cost. MethodsBased on data from 1,365 adult patients with video‐electroencephalography–confirmed diagnoses from a single center, we used logistic and Poisson regression to compare ...
Source: Epilepsia - Category: Neurology Authors: Tags: Full ‐Length Original Research Source Type: research
This article will review the profile of topiramate that has emerged out of the past decade of research and clinical use in migraine prophylaxis. It will also address the rationale for extended-release (XR) formulations in optimizing topiramate therapy in migraine. SUMMARY: Topiramate has activity at multiple molecular targets, which may account for why it is effective in migraine and most other, more specific, anticonvulsants are not. Based on randomized controlled trials, topiramate reduces migraine frequency and acute medication use, improves quality of life, and reduces disability in patients with episodic migraine...
Source: Headache - Category: Neurology Authors: Tags: Headache Source Type: research
This article will review the profile of topiramate that has emerged out of the past decade of research and clinical use in migraine prophylaxis. It will also address the rationale for extended‐release (XR) formulations in optimizing topiramate therapy in migraine. SummaryTopiramate has activity at multiple molecular targets, which may account for why it is effective in migraine and most other, more specific, anticonvulsants are not. Based on randomized controlled trials, topiramate reduces migraine frequency and acute medication use, improves quality of life, and reduces disability in patients with episodic migraine and ...
Source: Headache: The Journal of Head and Face Pain - Category: Neurology Authors: Tags: Headache Currents Source Type: research
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