Analgesic Impact of Single-Shot Versus Continuous Femoral Nerve Block After Total Knee Arthroplasty: A Systematic Review and Meta-Analysis

AbstractIntroductionEfficient pain management after total knee arthroplasty will accelerate functional recovery and reduce the length of hospital stay. The femoral nerve block is increasingly used in clinical practice owing to its favorable analgesic efficacy. However, the effect of continuous femoral nerve block compared to single-shot femoral nerve block remains controversial.MethodsThree databases (Pubmed, Embase and Cochrane Library) were searched for randomized controlled trials up to April 2019. Seven studies with 525 patients were included in this analysis.ResultsThe pooled estimates showed that the continuous femoral nerve block could relieve the pain at rest [standardized mean differences with 95% confidence intervals 1.12 (0.63 –1.60),I2 = 57%,p 
Source: Advances in Therapy - Category: Drugs & Pharmacology Source Type: research

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ConclusionOur evidence suggests that iguratimod may be considered a potential alternative to methotrexate to treat rheumatoid arthritis.Key Points•The Asia Pacific League of Association for Rheumatology (APLAR) has recommended that iguratimod may be used a first-line drug for rheumatoid arthritis in specific cases.•Patients on iguratimod may have similar treatment response, functional ability, disease state, and adverse event profile at 24  weeks compared with those on methotrexate.•Iguratimod may be considered a better alternative to methotrexate in RA patients having high CRP and ESR values.•Futu...
Source: Clinical Rheumatology - Category: Rheumatology Source Type: research
Conclusions: These data suggest biomarker analysis can reflect disease activity across disease domains in PsA. Certain domains would likely benefit from evaluation of additional biomarkers. PMID: 32067517 [PubMed - as supplied by publisher]
Source: Expert Review of Clinical Immunology - Category: Allergy & Immunology Tags: Expert Rev Clin Immunol Source Type: research
ARTHRITIS can be a debilitating condition, making everyday life feel like a pain. Could CBD be the answer to relieve symptoms of the inflammatory joint disease?
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
er Ali Alazmani Splinting techniques are widely used in medicine to inhibit the movement of arthritic joints. Studies into the effectiveness of splinting as a method of pain reduction have generally yielded positive results, however, no significant difference has been found in clinical outcomes between splinting types. Tactile sensing has shown great promise for the integration into splinting devices and may offer further information into applied forces to find the most effective methods of splinting. Hall effect-based tactile sensors are of particular interest in this application owing to their low-cost, small size,...
Source: Sensors - Category: Biotechnology Authors: Tags: Article Source Type: research
AbstractBakker et al found a change in the magnetic resonance imaging (MRI) findings in 29 of 188 patients, when the examination was repeated at three months and at one year (1). The patients were all being investigated on account of back pain, with presumably varying degrees of concern about the possibility of inflammatory spondyloarthritis.Twelve (6.8%) patients were negative at the initial examination but became positive on subsequent testing. A percentage that was lower, but not dissimilar to Van Onna et al's report of 15% at two years (2).
Source: Arthritis and Rheumatology - Category: Rheumatology Authors: Tags: LETTER TO THE EDITOR Source Type: research
Conditions:   Rheumatoid Arthritis;   Psoriatic Arthritis Intervention:   Drug: Cannabis: placebo and medium THC/medium CBD Sponsor:   Brown University Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
February 14, 2020 -- The U.S. Food and Drug Administration today approved three drugs for nonprescription, or over-the-counter (OTC), use through a process called a prescription (Rx)-to-OTC switch. The FDA approved Voltaren Arthritis Pain...
Source: Drugs.com - Daily MedNews - Category: General Medicine Source Type: news
AbstractPain is a health issue affecting all populations, regardless of age, gender, economic status, race, or geography. Acute pain is the most common type of pain, with a complex aetiology. Inadequately managed acute pain adversely affects quality of life and imposes significant economic burden. The majority of the available pain-relieving drugs have monomodal mechanisms of analgesia, which necessitates combining drugs with non-redundant mechanisms of action in order to provide adequate pain relief and reduce the side effects from higher doses of individual drugs. In this regard, combining an oral opioid (such as codeine...
Source: Pain and Therapy - Category: Anesthesiology Source Type: research
Conditions:   Rheumatoid Arthritis;   Psoriatic Arthritis Intervention:   Drug: Cannabis: placebo and medium THC/medium CBD Sponsor:   Brown University Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
ConclusionA review of the literature identified only few cases of closed avulsion of FDS tendons nonpathologically. Early diagnosis and intervention can prevent sequel of flexion contracture.
Source: International Journal of Surgery Case Reports - Category: Surgery Source Type: research
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