Antidiabetic effect of Cordia morelosana, chemical and pharmacological studies

Publication date: Available online 7 January 2020Source: Journal of EthnopharmacologyAuthor(s): Diana Giles-Rivas, Samuel Estrada-Soto, A. Berenice Aguilar-Guadarrama, Julio Almanza-Pérez, Sara García-Jiménez, Blanca Colín-Lozano, Gabriel Navarrete-Vázquez, Rafael Villalobos-MolinaAbstractEthnopharmacological importance Cordia morelosanaStandley (Boraginaceae) is commonly used in folk medicine for the treatment of diarrhoea, kidney inflammation, diabetes, lung pain, bronchitis, asthma, hoarseness, cough and fever.AimCurrent work was conducted to develop a bio-guided isolation of antidiabetic compounds from ethanolic extract of Cordia morelosana (EECm).Material and methodsThe phytochemical bio-guided study was conducted by successive chromatographic techniques, and isolated compounds were characterized by 1D and 2D-NMR experiments. The in vivo antihyperglycemic and antidiabetic activities of EECm (100 mg/kg), and methyl rosmarinate (MR, 50 mg/kg) were determined on normoglycemic and diabetic murine models. Additionally, the in vitro activity was conducted to determine α-glucosidase inhibitory effect, and PPARs expression on 3T3-L1 cells by RT-PCR. Acute and sub-chronic toxicological studies for EECm were conducted on rats, following the OECD guidelines (No. 420 and 407).ResultsEECm promotes significant α-glucosidase inhibition (55.6%) at 1 mg/kg respect to the control. Also, EECm (100 mg/kg) showed significant antihypergly...
Source: Journal of Ethnopharmacology - Category: Drugs & Pharmacology Source Type: research

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Source: Medical Ultrasonography - Category: Radiology Tags: Med Ultrason Source Type: research
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Source: Medical Ultrasonography - Category: Radiology Tags: Med Ultrason Source Type: research
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Source: Endocrine, Metabolic and Immune Disorders Drug Targets - Category: Drugs & Pharmacology Tags: Endocr Metab Immune Disord Drug Targets Source Type: research
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AbstractInformation about the effects of photoperiod on the testicular transcriptome of broiler roosters is limited. The aim of the present study was to explore the effect of different photoperiodic regimes on gene expression in the testes of broiler breeder roosters. One hundred and twenty Arbor Acres broiler breeder roosters aged 20  weeks were assigned to one of three groups (n = 40) and subjected to different photoperiodic regimes: control (CTR; 12.5 L:11.5 D), short day (SD; 8 L:16 D) and long day (LD; 16 L:8 D). After 4 weeks, the testes of 10 randomly selected birds from each group were dissected...
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Source: International Journal for Vitamin and Nutrition Research - Category: Nutrition Tags: Int J Vitam Nutr Res Source Type: research
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Source: Channels - Category: Molecular Biology Tags: Channels (Austin) Source Type: research
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