Gastric Atrophy and its Interaction with Poor Oral Health Elevate the Risk for Esophageal Squamous Cell Carcinoma in a High-risk Region of China: a Population-based Case-control Study.

Gastric Atrophy and its Interaction with Poor Oral Health Elevate the Risk for Esophageal Squamous Cell Carcinoma in a High-risk Region of China: a Population-based Case-control Study. Am J Epidemiol. 2020 Jan 03;: Authors: Ekheden I, Yang X, Chen H, Chen X, Yuan Z, Jin L, Lu M, Ye W Abstract Previous findings concerning gastric atrophy as a potential risk factor for esophageal squamous cell carcinoma (ESCC) have been inconsistent. Our aim was to test whether gastric atrophy, and further its interaction with poor oral health, elevate the risk for ESCC in a high-risk region of China. Our population-based case-control study in Taixing, China from 2010-2014, recruited cases from local hospitals and the local cancer registry. Controls were selected randomly from the local population registry. Ultimately, 1210 cases and 1978 controls answered questionnaire and provided blood samples for assay of pepsinogens. Unconditional logistic regression models were utilized to estimate odds ratios (ORs) and 95% confidence intervals (CI). Gastric atrophy (defined as a serum level of pepsinogen I
Source: Am J Epidemiol - Category: Epidemiology Authors: Tags: Am J Epidemiol Source Type: research

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