Marked coagulopathy without liver disease or anticoagulation therapy

Publication date: Available online 26 December 2019Source: Clinics and Research in Hepatology and GastroenterologyAuthor(s): Kevin Jurgensmeier, Lee J. Hixson, David C. PfeifferSummarySymptomatic coagulopathies in celiac disease (CD) are rare. Here, we report a profound case of coagulopathy in a celiac. A 66-year old female without liver disease or anti-coagulation therapy presented with multiple ecchymoses, guaiac positive melanic stool, and a recent 4.5 kg weight loss. Laboratory values included hemoglobin, 3.8 g/dL; MCV, 66 fL; serum iron, 17 μg/dL; platelet count, 580 K/μL; white count, 14.2 K/μL, and vitamin D, < 5.0 ng/mL. Additional values included partial thromboplastin time (PTT),> 200 s; prothrombin time (PT),> 150 s; INR, 20.5, putting her at extreme risk of bleeding. Vitamin K deficiency was assumed. The patient was given two units of fresh frozen plasma, packed red cells, and vitamin K intravenously. Endoscopy and biopsies demonstrated duodenal mucosal atrophy with cobblestoning, erosive gastritis, flattened duodenal villi and numerous intraepithelial lymphocytes. Transglutaminase serology demonstrated IgA TTG > 100 U/mL (normal < 3 U/mL), confirming a diagnosis of CD. The patient's coagulopathy resolved within two days following admission. This case underscores the importance of CD testing in all patients with coagulopathies of unknown origin. Although coagulopathy is...
Source: Clinics and Research in Hepatology and Gastroenterology - Category: Gastroenterology Source Type: research