Treatment of oral chronic graft-vs-host disease with clobetasol: case report

Graft-vs-host disease (GVHD) is the main complication of allogeneic hematopoietic stem cells transplantation. A 29-year-old Brazilian man was diagnosed as having severe aplastic anemia and submitted to allogeneic HSCT in October 2013. He developed systemic chronic GVHD, including the oral cavity (lichenoid lesions in right and left buccal mucosa and labial hyperchromia and was treated with mycophenolate mofetil, tacrolimus, cyclosporine, and dexamethasone solution [mouthwash]). Upon stabilization of chronic GVHD in the oral cavity, the patient displayed gingival atrophy and erythema (12-21/33-42) on July 27, 2017.

Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics - December 15, 2019 Category: ENT & OMF Authors: BARBARA BARRETO PACHECO VALENTIM, GABRIELA DE ASSIS RAMOS, CAMILA BRAND ÃO LOBO, TAÍSA DOMINGUES BERNARDES SILVA, HELITON SPINDOLA ANTUNES Source Type: research