Neuropsychiatric Symptoms of Multiple Sclerosis: State of the Art.

Neuropsychiatric Symptoms of Multiple Sclerosis: State of the Art. Psychiatry Investig. 2019 Dec 09;: Authors: Silveira C, Guedes R, Maia D, Curral R, Coelho R Abstract Multiple Sclerosis (MS) is a chronic disabling neuroinflammatory disease. Psychiatric manifestations have a high prevalence in MS patients and may worsen the illness progression and the patients' quality of life (QoL). Depression is a highly prevalent condition in MS patients, associated with poorer adherence to treatment, decreased functional status and QoL, and increased suicide risk. Diagnosis and treatment of this disorder is challenging because of symptom overlap. Other prevalent psychiatric comorbidities are anxiety disorders, bipolar disorder, psychotic disorders, substance misuse and personality disorders. As the illness progresses, personality changes can happen, as well as affect abnormalities. Cognitive changes occur frequently in MS patients, and affect features like processing speed, attention, learning, memory, visual spatial capabilities, and some language deficits. Disease-modifying treatments may reduce cognitive impairment because of their container action on the brain's lesion burden. Other QoL determinants such as fatigue, pain, sexual dysfunction, exercise, resilience and social support should be taken into account, in order to promote the individuals' well-being. Further studies are needed in order to elucidate the effectiveness of pharmacotherapy and more neuroimagin...
Source: Psychiatry Investigation - Category: Psychiatry Tags: Psychiatry Investig Source Type: research

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Authors: Barton BB, Segger F, Fischer K, Obermeier M, Musil R Abstract Introduction: Antipsychotic-induced weight-gain (AIWG) is a very important, yet often neglected side-effect in the treatment with first and second generation antipsychotics. AIWG can increase the risk of developing metabolic syndrome, diabetes and cardiovascular disease. Meta-analyses mostly concentrate on AIWG in schizophrenic and bipolar patients, even though antipsychotics are prescribed off-label across many other diagnostic groups (e.g. anxiety disorders, depression, autistic disorder).Areas covered: Pub Med and Web of Science were systemat...
Source: Expert Opinion on Drug Safety - Category: Drugs & Pharmacology Tags: Expert Opin Drug Saf Source Type: research
In this study, we discovered that chronic alcohol treatment increased editing of RNA of 5-HT2CR via up-regulating the expression of ADAR2, consequently reducing the release of ATP from astrocytes induced by 5-HT2CR agonist, MK212. Moreover, SSRI antidepressant fluoxetine decreased the expression of ADAR2 through the transactivation of EGFR/PI3K/AKT/cFos signalling pathway. The increased release of astroglial ATP by MK212 which was suppressed by chronic alcohol consumption, and reduction in ADAR2 activity eliminated the RNA editing of 5-HT2CR increased by alcohol in vitro and recovered the release of ATP from astrocytes ind...
Source: Neurochemistry International - Category: Neuroscience Source Type: research
This article includes references to self-injury, intravenous drug use and disordered eating.* One in five US high school students have reported being bullied. Approximately 160,000 teenagers have skipped school as a preventative measure. I encountered bullies for the first time in second grade, in the midst of such an innocent time of my youth. I dreaded entering my elementary school classroom, as I was well aware of what my presence would entail. I endured both verbal and physical harassment from my fellow peers for nearly a decade. I was passive, inevitably leading to the acceptance of my “fate,” in addition ...
Source: Psych Central - Category: Psychiatry Authors: Tags: Addictions Anorexia Bullying Depression Eating Disorders Personal Stories Substance Abuse Addiction Recovery Anorexia Nervosa Drug Use heroin Self Harm Self Injury Source Type: news
Publication date: Available online 20 January 2020Source: Veterinary Immunology and ImmunopathologyAuthor(s): Tatianna F.S. De Nardo, Paulo H.L. Bertolo, Priscila A. Bernardes, Danísio P. Munari, Gisele F. Machado, Luciana S. Jardim, Pamela R.R. Moreira, Mayara C. Rosolem, Rosemeri O. VasconcelosABSTRACTMacrophage migration inhibitory factor (MIF) is a pleiotropic cytokine that is produced by many cell types in situations of homeostasis or disease. One of its functions is to act as a proinflammatory molecule. In humans, several studies have shown that MIF levels become elevated in the serum, urine, cerebrospinal flu...
Source: Veterinary Immunology and Immunopathology - Category: Veterinary Research Source Type: research
Jeffrey A. SingerOn January 20th, theCincinnati Enquirer ran a story on the recentreport from the Centers for Disease Control and Prevention that showed a 30.1 percent drop in prescription opioid volume from 2010  – 2011 to 2016 – 2017. While the CDC report was non‐​judgmental, it was greeted by hospital administrators and emergency physicians in the Cincinnati area as good news.The article quotes one physician/ ​hospital spokesperson as saying:“The patient can know, ‘My encounter with the ED will … lead to a good outcome. I will not be ex...
Source: Cato-at-liberty - Category: American Health Authors: Source Type: blogs
The risk of developing bipolar disorder was increased in women with PCOS, possibly because of shared inflammatory pathways, a study has found; metformin may have a protective effect.Medscape Medical News
Source: Medscape Psychiatry Headlines - Category: Psychiatry Tags: Ob/Gyn & Women ' s Health News Source Type: news
RESUMO Objetivo: Avaliar o impacto de um protocolo de manejo da dor e redu ção do consumo de opioides no consumo geral de opioides e nos desfechos clínicos. Métodos: Estudo em centro único, quasi-experimental, retrospectivo, de coortes antes e depois. Utilizamos uma série temporal interrompida para analisar as alterações no nível e na tendência de utilização d e diferentes analgésicos. Foram usadas comparações bivariadas nas coortes antes e depois, regressão logística e regressão quantílica pa...
Source: Revista Brasileira de Terapia Intensiva - Category: Intensive Care Source Type: research
RESUMO Os pacientes com s índrome do desconforto respiratório agudo requerem estratégias ventilatórias que demonstraram ser importantes na redução da mortalidade em curto prazo, como ventilação protetora e ventilação em posição prona. No entanto, os pacientes que sobrevivem têm permanência prolongada, tanto na unidade de terapia intensiva como no hospital, e experimentam redução na satisfação global com a vida (independência, aceitação e perspectiva positiva), na saúde menta...
Source: Revista Brasileira de Terapia Intensiva - Category: Intensive Care Source Type: research
Conclusion: Ambas as escalas são adequadas para a avaliação da dor em pacientes intubados orotraquealmente, internados em unidade de terapia intensiva, contudo, apresentam limitações em populações específicas como doentes vítimas de trauma, queimados e do f oro neurocirurgico. É sugerida a realização de mais estudos sobre o tema e em populações específicas.
Source: Revista Brasileira de Terapia Intensiva - Category: Intensive Care Source Type: research
BACKGROUND: Suicide is a leading cause of death among adolescents in North America. Youth who present to the Emergency Department (ED) with acute suicidality are at increased risk for eventual death by suicide, thereby presenting an opportunity for seconda...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Adolescents Source Type: news
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