Developments in Artificial Platelet and Erythroid Transfusion Products.

Developments in Artificial Platelet and Erythroid Transfusion Products. Adv Exp Med Biol. 2019 Dec 05;: Authors: Meric N, Guney Esken G, Uslu M, Kocabas F Abstract Platelet and blood transfusions have vital importance to the lives of many patients. Platelet transfusions are a life-saving intervention by reducing risk of bleeding in thrombocytopenic patients. Due to the short shelf life of platelets and their limited availability, researchers have developed various platelet transfusion production technologies. Understanding the cellular and biophysical mechanisms of platelet release is particularly important for development of platelet transfusion products (PTPs) and to translate them to clinical applications in patients requiring platelet infusion. Similarly, due to donor dependence and increased clinical need of blood transfusions, studies on the erythroid transfusion products (ETPs) have recently gained momentum. This led to development of ETP technologies involving differentiation of stem cells to fully functional erythrocytes in vitro. During megakaryopoiesis or erythropoiesis, various stimulatory factors, growth factors, transcription factors, and biophysical conditions have been shown to play a crucial role in the formation final blood products. Thus, understanding of the in vivo mechanisms of platelet release and erythrocyte maturation is particularly important for mimicking these conditions in vitro. This review focuses on latest and up-to-date in...
Source: Advances in Experimental Medicine and Biology - Category: Research Tags: Adv Exp Med Biol Source Type: research

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AbstractObjectivesThe purpose of this study was to investigate whether the genetic variations which could regulate inflammatory responses were associated with the risk of peri-implantitis.Materials and methodsWe evaluated three genetic variants including tumor necrosis factor-alpha (TNF- α) − 308G/A, interleukin-1 alpha (IL-1A) − 889C/T, and IL-1 beta (IL-1B) + 3954C/T, as risk factors for peri-implantitis, in a total of 144 patients with peri-implantitis and 174 healthy controls in a Chinese non-smoking population.ResultsLogistic regression analyses revealed that subjects carrying th...
Source: Clinical Oral Investigations - Category: Dentistry Source Type: research
Prophylaxis with proton-pump inhibitors (PPIs) or histamine-2-receptor antagonists (H2RAs) significantly reduces gastrointestinal bleeding in higher-risk critically ill patients, but not in patients at low risk of bleeding, according to a systematic review and network meta-analysis.Reuters Health Information
Source: Medscape Critical Care Headlines - Category: Intensive Care Tags: Gastroenterology News Source Type: news
AbstractPurpose of ReviewRobert ( “Bob”) Genco was a member of the research team that established the Buffalo Osteoporosis and Periodontal Disease (OsteoPerio) study. Here we detail the scientific discoveries emanating from this enduring collaboration.Recent FindingsOsteoPerio is ancillary to the Women ’s Health Initiative Observational Study (WHI-OS). WHI-OS is a longitudinal study of 93,676 postmenopausal women aged 50–79 enrolled at 40 US centers (enrolled in 1993–1998). OsteoPerio enrolled 1342 women 3 years later (1997–2001) from the Buffalo WHI-OS participants to study the ass...
Source: Current Oral Health Reports - Category: Dentistry Source Type: research
The aim of the present study was to assess the clinical safety profile of dental extractions in patients with thrombocytopenia and explore the effectiveness of platelet transfusion before dental extractions.
Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics - Category: ENT & OMF Authors: Tags: Original Article Source Type: research
AbstractIn the era of neoadjuvant chemoradiotherapy/radiotherapy and total mesorectal excision, overall oncological outcomes after curative resection of rectal cancer are excellent, with local recurrence rates as low as 5 –10%. However, lateral nodal disease is a major cause of local recurrence after neoadjuvant chemoradiotherapy/radiotherapy and total mesorectal excision. Patients with lateral nodal disease have a local recurrence rate of up to 30%. The oncological benefits of lateral pelvic lymph node dissection (LPLND) in reducing local recurrence, particularly in the lateral compartment, have been demonstrated. A...
Source: Surgery Today - Category: Surgery Source Type: research
To compare the outcomes in trans-femoral transcatheter aortic valve implantation (TF-TAVI) performed with percutaneous approach (PC) versus surgical cut-down (SC). In 13 trials including 5859 patients (PC=3447, SC= 2412), the outcomes based on Valve Academic Research Consortium (VARC) criteria were compared between PC and SC in TF-TAVI. Compared with SC, PC was associated with similar major vascular complications (VCs) (8.7% vs. 8.5%; OR=0.93, 95% CI=0.76-1.15, p=0.53), major bleeding (OR=1.09, 95% CI=0.66-1.8, p=0.73), perioperative mortality (5.7% vs.
Source: The American Journal of Cardiology - Category: Cardiology Authors: Source Type: research
ConclusionsWe found adequate evidence supporting the use of surgery for the treatment of symptomatic isthmocele, as it was found to improve the bleeding symptoms in more than 80% of patients. Differently, we found a lack of evidence regarding the role of surgery with the purpose of improving fertility or reducing the risk of obstetric complications in women with asymptomatic isthmocele. The hysteroscopic correction of isthmocele may be the safest and most effective strategy in those patients with adequate residual myometrial thickness overlying the isthmocele. Laparoscopic and vaginal surgeries may be the preferred options...
Source: Archives of Gynecology and Obstetrics - Category: OBGYN Source Type: research
ConclusionsPillar suture combined with tonsillectomy may reduce postoperative bleeding incidence despite increasing pillar edema in pediatric tonsillectomy. Postoperative pain-relief, palatal hematoma, palatal discomfort sensation, site infection, and velopharyngeal insufficiency were not significantly altered compared to tonsillectomy alone. However, further studies are needed to corroborate the results of this study.ResumoIntroduçãoDiversas técnicas cirúrgicas têm sido utilizadas na tonsilectomia no intuito de reduzir complicações.ObjetivosAvaliar os efeitos da sutura dos p...
Source: Brazilian Journal of Otorhinolaryngology - Category: ENT & OMF Source Type: research
Conclusion: It may be employed either alone or in combination with cryotherapy, existing chemotherapy, bypass surgery or radiations to achieve the optimal results in these patients. Nevertheless, there is a need to formulate a uniform dose and procedure to achieve homogeneity and develop references for clinical practices. PMID: 31977258 [PubMed - as supplied by publisher]
Source: International Journal of Radiation Biology - Category: Radiology Tags: Int J Radiat Biol Source Type: research
Authors: Ashour AS, Dey N, Mohamed WS, Tromp JG, Sherratt RS, Shi F, Moraru L Abstract Wireless Capsule Endoscopy (WCE) is a highly promising technology for gastrointestinal (GI) tract abnormality diagnosis. However, low image resolution and low frame rates are challenging issues in WCE. In addition, the relevant frames containing the features of interest for accurate diagnosis only constitute 1% of the complete video information. For these reasons, analyzing the WCE videos is still a time consuming and laborious examination for the gastroenterologists, which reduces WCE system usability. This leads to the emergent...
Source: Current Medical Imaging Reviews - Category: Radiology Tags: Curr Med Imaging Rev Source Type: research
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