Abnormal expression of liver autophagy and apoptosis-related mRNA in fatty liver hemorrhagic syndrome and improvement function of resveratrol in laying hens.

Abnormal expression of liver autophagy and apoptosis-related mRNA in fatty liver hemorrhagic syndrome and improvement function of resveratrol in laying hens. Avian Pathol. 2019 Nov 27;:1-26 Authors: Wang X, Xing C, Yang F, Zhou S, Li G, Zhang C, Cao H, Hu G Abstract Fatty liver hemorrhagic syndrome (FLHS) is characterized by hepatic rupture and hemorrhage leading to sudden death in laying hens. Resveratrol (Res) is a natural polyphenol with antioxidant and anti-inflammatory effects that can ameliorate chronic liver disease. The aim of this study is to investigate the improved effect of Res on the altered expression of autophagy and apoptosis-related genes in laying hens with FLHS. A total of 144 healthy 150-day-old laying hens were randomly divided into four group: control group (standard diet), HELP group (high-energy-low-protein (HELP) diet), HELP + Res group (HELP diet with 400 mg/kg Res) and Res group (standard diet with 400 mg/kg Res). Histopathological lesions of the liver and the mRNA levels of Beclin-1, Atg5, Atg7, p62, Bcl-2, Bax and Caspase-3 on days 40, 80, and 120 were measured. The results showed that lipid accumulation and hepatocyte damage in HELP group were more serious than those in HELP + Res group. The mRNA levels of Beclin-1, Atg5, Atg7, and Bcl-2 in HELP and HELP + Res groups were strikingly declined (P < 0.01) compared to the control group, and their mRNA levels were markedly higher in HEL...
Source: Avian Pathology - Category: Pathology Authors: Tags: Avian Pathol Source Type: research