Methicillin-resistant Staphylococcus aureus (MRSA) is an important pathogen in erythrodermic cutaneous T-cell lymphoma (CTCL) patients

AbstractErythroderma can occur in cutaneous T-cell lymphoma (CTCL).Staphylococcus aureus (S. aureus) prevalence is increased in CTCL patients and contributes to CTCL disease flares. Our primary aim was to describeS. aureus infections, including resistance patterns and the antibiotic treatment regimens used, in erythrodermic CTCL patients. This was a retrospective chart review of erythrodermic CTCL patients who hadS. aureus infection or colonization and were treated at the UT MD Anderson Cancer Center ’s Melanoma Skin Center between 2012 and 2016. Twenty-six erythrodermic CTCL patients had 50 documentedS. aureus colonization or infection events. Patients had an improvement in body surface area (BSA) or modified Severity Weighted Assessment Tool (mSWAT) in 53% events treated forS. aureus. Seventeen of the 50 (34%) events were due to methicillin-resistantS. aureus (MRSA). One-third (33%) of MRSA events were initially treated with dicloxacillin. The MRSA isolates were sensitive to trimethoprim –sulfamethoxazole (92%) and doxycycline (88%). Patients treated in the outpatient setting (OR 0.073; 95% CI 0.008–0.627;p = 0.017) and patients with a previous history of topical anti-S. aureus decolonization treatments beforeS. aureus event as stand-alone (OR 0.125; 95% CI 0.018 –0.887;p = 0.038) or in combination treatment with systemic antibiotics (OR 0.094; 95% CI 0.009–0.944;p = 0.045) were less likely to see improvement in BSA or mSWAT fromS. aureus treatment. Tr...
Source: Archives of Dermatological Research - Category: Dermatology Source Type: research