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Adding Anti-MRSA to Cephalexin No Better for Simple Cellulitis Adding Anti-MRSA to Cephalexin No Better for Simple Cellulitis
Cephalexin plus trimethoprim-sulfamethoxazole yielded no better clinical cure rates than cephalexin monotherapy, a new study has found.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - May 24, 2017 Category: Consumer Health News Tags: Infectious Diseases News Source Type: news

Adding TMP/SMX to Cephalexin May Not Boost Cure Rate in Uncomplicated Cellulitis (FREE)
By Amy Orciari Herman Edited by David G. Fairchild, MD, MPH, and Lorenzo Di Francesco, MD, FACP, FHM For patients with uncomplicated cellulitis, adding trimethoprim-sulfamethoxazole (TMP/SMX) to cephalexin may offer no benefit beyond cephalexin alone, a JAMA study finds.Some 500 patients older than 12 years seen in … (Source: Physician's First Watch current issue)
Source: Physician's First Watch current issue - May 24, 2017 Category: Primary Care Source Type: news

Relapses Common with S. Aureus Nasal Carriage in ANCA-Related Vasculitis (CME/CE)
(MedPage Today) -- Trimethoprim/sulfamethoxazole prophylaxis had no influence on relapse rate (Source: MedPage Today Rheumatology)
Source: MedPage Today Rheumatology - March 6, 2017 Category: Rheumatology Source Type: news

Sulfatrim (Sulfamethoxazole and Trimethoprim Oral Suspension) - updated on RxList
(Source: RxList - New and Updated Drug Monographs)
Source: RxList - New and Updated Drug Monographs - February 1, 2017 Category: Drugs & Pharmacology Source Type: news

Bactrim (Trimethoprim and Sulfamethoxazole) - updated on RxList
(Source: RxList - New and Updated Drug Monographs)
Source: RxList - New and Updated Drug Monographs - December 25, 2016 Category: Drugs & Pharmacology Source Type: news

Gantanol (Sulfamethoxazole) - updated on RxList
(Source: RxList - New and Updated Drug Monographs)
Source: RxList - New and Updated Drug Monographs - December 25, 2016 Category: Drugs & Pharmacology Source Type: news

Cheap Drugs May Have Turned This Indian Lake Into A 'Superbug Hotspot'
Centuries ago, Indian princes would bathe in the cool Kazhipally lake in Medak. Now, even the poorest villagers here in India’s baking south point to the barren banks and frothy water and say they avoid going anywhere near it. A short drive from the bustling tech hub of Hyderabad, Medak is the heart of India’s antibiotics manufacturing business: a district of about 2.5 million that has become one of the world’s largest suppliers of cheap drugs to most markets, including the United States. But community activists, researchers and some drug company employees say the presence of more than 300 drug firms, com...
Source: Healthy Living - The Huffington Post - September 29, 2016 Category: Consumer Health News Source Type: news

Make the Diagnosis: Blistering Mystery
(MedPage Today) -- Case Findings: A 34-year-old woman was brought to urgent care by her husband. She had a widespread dusky red rash that was beginning to blister. During her intake, the nurse noted the patient had recently been prescribed trimethoprim-sulfamethoxazole for a urinary tract infection. When the doctor put pressure on a lesion, he observed Nikolskys sign. The patient also complained of mouth pain and a sore throat, and the doctor could observe lesions forming on her mucosal lip. What is your diagnosis? (Source: MedPage Today Dermatology)
Source: MedPage Today Dermatology - March 22, 2016 Category: Dermatology Source Type: news

TMP-SMX Resistance in Pediatric Recurrent UTIs Higher after Prophylaxis but Declines Over Time (FREE)
By Christine Judge Edited by Susan Sadoughi, MD, and André Sofair, MD, MPH Prophylaxis with trimethoprim-sulfamethoxazole (TMP-SMX) in children with symptomatic urinary tract infection (UTI) and vesicoureteral reflux is associated with higher incidence of TMP-SMX resistance in recurrent infections but not … (Source: Physician's First Watch current issue)
Source: Physician's First Watch current issue - March 14, 2016 Category: Primary Care Source Type: news

Better way to treat abscesses: Add antibiotic to conventional approach
UCLA researchers have found that doctors can use a specific antibiotic in addition to surgically draining an abscess to give people a better chance of recovery. The discovery turns on its head the long-held notion that surgical drainage alone is sufficient for treating abscesses. The findings are particularly important because of the emergence of community-acquired methicillin-resistant Staphylococcus aureus, or MRSA, which since 2000 has become the most common cause of skin infections — initially in the U.S. and now in many other parts of the world. The UCLA study will be published March 3 by the New England Journal...
Source: UCLA Newsroom: Health Sciences - March 3, 2016 Category: Universities & Medical Training Source Type: news

Skin Abscess Outcomes Improve With Antibiotics PostdrainageSkin Abscess Outcomes Improve With Antibiotics Postdrainage
Adjunctive trimethoprim-sulfamethoxazole led to higher cure rates than drainage alone in a randomized trial of patients with uncomplicated skin abscesses treated in the emergency department. Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - March 3, 2016 Category: Consumer Health News Tags: Internal Medicine News Source Type: news

Limited Access to Pyrimethamine Prompts Update of Toxoplasmosis Section of the Adult and Adolescent OI Guidelines
The Toxoplasma gondii Encephalitis section of the Guidelines for the Prevention and Treatment of Opportunistic Infections in HIV-Infected Adults and Adolescents has been updated to provide clinicians with guidance on the use of trimethoprim-sulfamethoxazole for treatment of acute infection and chronic maintenance therapy for suspected or documented toxoplasmosis if pyrimethamine is not readily available.   On September 10, 2015, the OI Guidelines author panel issued this Notice of Availability of Pyrimethamine, which is guidance on what to do if pyrimethamine is unavailable to treat or prevent Toxoplasma encephalitis,...
Source: AIDSinfo At-a-Glance: Offering Information on HIV/AIDS Treatment, Prevention, and Research, A Service of the U.S. Department of Health and Human Services (DHHS) - October 19, 2015 Category: Infectious Diseases Source Type: news

Availability of Pyrimethamine: Statement from Adult & Adolescent OI Guideline Panel
Pyrimethamine is recommended for treatment and/or prophylaxis of Toxoplasma encephalitis, Pneumocystis pneumonia, and Isospora infection. As of June 2015, pyrimethamine is no longer available in retail pharmacies in the United States. It is only available through a special pharmacy program (http://www.daraprimdirect.com/how-to-prescribe). If there is a delay in procuring pyrimethamine for a patient in whom it is needed for one of the above indications, please refer to the specific pathogen section for alternative drug regimens for treatment or prophylaxis. For patients with suspected or documented toxoplasmosis who do not ...
Source: AIDSinfo At-a-Glance: Offering Information on HIV/AIDS Treatment, Prevention, and Research, A Service of the U.S. Department of Health and Human Services (DHHS) - September 11, 2015 Category: Infectious Diseases Source Type: news

Darunavir and Trimethoprim-Sulfamethoxazole Cross-ReactivityDarunavir and Trimethoprim-Sulfamethoxazole Cross-Reactivity
This study examines the cross-reactivity between both drugs. AIDS (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - May 25, 2015 Category: Consumer Health News Tags: HIV/AIDS Journal Article Source Type: news

Scientists 'amazed' at spread of typhoid 'superbug'
ConclusionThis study has provided information about the spread of a strain of typhoid called H58, which is commonly antibiotic-resistant, by looking at the genetics of samples collected between 1903 and 2013. It has shown that the strain was likely to have arisen in South Asia and then spread to Southeast Asia and Africa. The strain showed different patterns of antibiotic resistance in different regions – likely driven by different patterns in the use of antibiotics. While this study has not estimated the number of cases or deaths worldwide attributable to this strain specifically, there are reported to be 20-30 mill...
Source: NHS News Feed - May 12, 2015 Category: Consumer Health News Tags: Medical practice Source Type: news

Two Popular Antibiotics Equally Effective in Skin InfectionsTwo Popular Antibiotics Equally Effective in Skin Infections
The popular antibiotics clindamycin and trimethoprim-sulfamethoxazole are essentially equivalent in treating outpatients with uncomplicated skin infections, according to a randomized controlled trial. Medscape Medical News (Source: Medscape Dermatology Headlines)
Source: Medscape Dermatology Headlines - March 19, 2015 Category: Dermatology Tags: Infectious Diseases News Source Type: news

TMP-SMX and Clindamycin Offer Similar Efficacy for Uncomplicated Skin Infections (FREE)
By Larry M. Baddour, MD Trimethoprim-sulfamethoxazole (TMP-SMX) and clindamycin lead to similar cure rates in patients with uncomplicated skin infections, according to a New England Journal of Medicine study.Researchers enrolled some 500 outpatients (mean age, 27) with cellulitis, … (Source: Physician's First Watch current issue)
Source: Physician's First Watch current issue - March 19, 2015 Category: Primary Care Source Type: news

Choosing An Antibiotic For Skin Infections--What's Best?
A new study in the New England Journal of Medicine on treatment of skin infections compares treatment with trimethoprim sulfamethoxazole (TMP-SMX, Bactrim or Septra) or clindamycin. Surprisingly, both worked equally well in this 524 patient study, curing about 89% of outpatients with uncomplicated skin infections cellulitis and abscesses, so the authors appear to encourage use of one of these drugs because they are better at treating MRSA than are currently recommended antibiotics. (Source: Forbes.com Healthcare News)
Source: Forbes.com Healthcare News - March 18, 2015 Category: Pharmaceuticals Authors: Judy Stone Source Type: news

Clindamycin, TMP-SMX are equally effective for skin infections
Clindamycin and trimethoprim-sulfamethoxazole are similarly safe and effective for treating uncomplicated skin infections, including both cellulitis and abscesses, in ambulatory settings in regions where MRSA is endemic, according to a report published online March 19 in the New England Journal of... (Source: Skin and Allergy News)
Source: Skin and Allergy News - March 18, 2015 Category: Dermatology Tags: CME-candidate EM Journals EM Clinical News EM News EM Dermatology EM Infectious Disease FPN Journals FPN News Source Type: news

Two commonly used antibiotics have similar cure rates for uncomplicated skin infections
(Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center (LA BioMed)) Two antibiotics frequently prescribed to treat serious skin infections -- clindamycin and trimethoprim sulfamethoxazole (TMP-SMX) -- had similar rates of success in curing uncomplicated infections in outpatients. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - March 18, 2015 Category: Infectious Diseases Source Type: news

Antibiotic, Spironolactone Combo Ups Sudden Death in Elderly Antibiotic, Spironolactone Combo Ups Sudden Death in Elderly
When combined with spironolactone, a diuretic, trimethoprim-sulfamethoxazole is riskier than other antibiotics in people older than 65 years. Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - February 3, 2015 Category: Consumer Health News Tags: Internal Medicine News Source Type: news

Commonly used antibiotics with diuretic can double risk of sudden death in older patients
The combination of the commonly prescribed antibiotic trimethoprim-sulfamethoxazole with the diuretic spironolactone, widely used for heart failure, more than doubles the risk of death for older patients, reports a study. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - February 2, 2015 Category: Science Source Type: news

Certain Heart Drug, Antibiotic Combo Might Be Fatal for Seniors
Doctors should not prescribe spironolactone with trimethoprim-sulfamethoxazole, study saysSource: HealthDay Related MedlinePlus Pages: Drug Reactions, Medicines, Seniors' Health (Source: MedlinePlus Health News)
Source: MedlinePlus Health News - February 2, 2015 Category: Consumer Health News Source Type: news

Concomitant Use of TMP-SMX and Common BP Drugs Linked to Sudden Death (FREE)
By Amy Orciari Herman Edited by André Sofair, MD, MPH, and William E. Chavey, MD, MS Among older patients taking angiotensin-converting enzyme (ACE) inhibitors or angiotensin receptor blockers (ARBs), concomitant use of the antibiotic trimethoprim-sulfamethoxazole is associated with increased risk for sudden death, … (Source: Physician's First Watch current issue)
Source: Physician's First Watch current issue - October 31, 2014 Category: Primary Care Source Type: news

Doctors issue new treatment guidelines for skin abscesses caused by MRSA
It has been more than 10 years since the clinical battle began with community-acquired methicillin-resistant Staphylococcus aureus (MRSA), and doctors are still grappling with how to diagnose, treat and prevent this virulent form of staph infection, which is immune to many antibiotics.   As MRSA cases have increased dramatically over the decade, so have the number of skin abscesses — generally pus-filled boils or pimples with discharge — that characterize these infections. Now, researchers from UCLA have issued updated guidelines outlining the best ways to treat and manage these abscesses.   The ...
Source: UCLA Newsroom: Health Sciences - March 12, 2014 Category: Universities & Medical Training Source Type: news

Doctors issue new treatment guidelines for skin abscesses caused by MRSA
It has been more than 10 years since the clinical battle began with community-acquired methicillin-resistant Staphylococcus aureus (MRSA), and doctors are still grappling with how to diagnose, treat and prevent this virulent form of staph infection, which is immune to many antibiotics. As MRSA cases have increased dramatically over the decade, so have the number of skin abscesses — generally pus-filled boils or pimples with discharge — that characterize these infections. Now, researchers from UCLA have issued updated guidelines outlining the best ways to treat and manage these abscesses. The first cas...
Source: UCLA Newsroom: Health Sciences - March 12, 2014 Category: Universities & Medical Training Source Type: news

TMP-SMX Prevents Ocular Toxoplasmosis RecurrenceTMP-SMX Prevents Ocular Toxoplasmosis Recurrence
Extended treatment with trimethoprim-sulfamethoxazole may reduce the risk of recurrence in patients with Toxoplasma gondii retinochoroiditis (TGR), according to a new study of 95 patients. Reuters Health Information (Source: Medscape Ophthalmology Headlines)
Source: Medscape Ophthalmology Headlines - January 27, 2014 Category: Opthalmology Tags: Ophthalmology News Source Type: news

Treatment of Infections Due to Resistant Staphylococcus aureus
This chapter reviews data on the treatment of infections caused by drug-resistant Staphylococcus aureus, particularly methicillin-resistant S. aureus (MRSA). This review covers findings reported in the English language medical literature up to January of 2013. Despite the emergence of resistant and multidrug-resistant S. aureus, we have seven effective drugs in clinical use for which little resistance has been observed: vancomycin, quinupristin–dalfopristin, linezolid, tigecycline, telavancin, ceftaroline, and daptomycin. However, vancomycin is less effective for infections with MRSA isolates that have a higher MIC w...
Source: Springer protocols feed by Microbiology - October 6, 2013 Category: Microbiology Source Type: news

Cholera and Diarrhea
CHOLERA and DIARRHEA At this very moment there is an outbreak of cholera in Zimbabwe– not a worldwide pandemic, but a localized epidemic. This is not a trivial point of interest, but a major news event that will not only have a dramatic impact on the population of Zimbabwe but also on the entire world as the aftermath of this epidemic will require international aid. Cholera will most likely kill thousands of people in Zimbabwe, impact tens of thousands of lives, and will continue to be a constant threat around the world and a very real concern for the adventurous and international travelers. What is cholera? Cholera...
Source: Wilderness Medicine Newsletter - January 1, 2009 Category: Rural Health Authors: wildernessmedicinenewsletter Tags: Cholera Diarrhea Source Type: news