Differences between men and women with COPD: The French Palomb Cohort

This study aimed to compare the COPD severity (GOLD III-IV vs I-II) in both women and men in PALOMB cohort.Diagnosed COPD patients were included by their pulmonologists. The following variables were collected: age, sex, BMI, FEV1, dyspnea (mMRC), the frequency of exacerbations, static hyperinflation (RV/TLC ≥130%) and comorbidities.35.64% of 2,259 COPD patients followed were women (64 average age). Statistically significant (P≤0.001) findings in female COPD patients were as follows: younger, underweight, more likely to be current cigarette smokers, more frequent static hyperinflation (76.1% vs 70.6%) and higher dyspnea. GOLD stage III was lower in women. Exacerbator phenotype was more frequent in women (31.9% vs 23.2%), regardless of their COPD severity. Anxiety (22.7% vs 9.2%) and depression (23.7% vs 9.2%) were more frequent in women. Adjusted multivariate analysis showed that: Hyperinflation: 5.78[3.99-8.36]; higher dyspnea: 2.74[1.96-3.82]; anxiety: 2.04[1.47-2.84]; asthma: 1.55[1.05-2.3] and frequent exacerbations: 1.39[1.04-1.86] were associated with COPD severity in women. Contrastingly in men: Hyperinflation: 7.39[5.81-9.4]; higher dyspnea: 2.8[2.21-3.54]; left heart failure: 1.75[1.13-2.71]; sputum: 1.62[1.32-2]; age: 1.39[1.11-1.74] and hypertension: 1.27[1.03-1.58] were associated with COPD severity.The results are reflective of the commonly found factors of poor prognosis in COPD women: Frequent exacerbations and underweight.Funding: Bordeaux University Foun...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Epidemiology Source Type: research