Pharmacological blockage of ICAM-1 improves angiotensin II-induced cardiac remodeling by inhibiting adhesion of LFA-1+ monocytes.

In conclusion, these results provide novel evidence that blocking ICAM-1 exerts a protective effect in Ang II-induced cardiac remodeling at least in part through the modulation of adhesion and infiltration of LFA-1+ macrophages in the heart. Inhibition of ICAM-1 may represent a new therapeutic approach for hypertrophic heart diseases.
PMID: 31729904 [PubMed - as supplied by publisher]

Source: American Journal of Physiology. Heart and Circulatory Physiology - November 14, 2019 Category: Physiology Authors: Lin QY, Lang PP, Zhang YL, Yang X, Xia Y, Bai J, Li HH Tags: Am J Physiol Heart Circ Physiol Source Type: research