Constitutive Activation of Natural Killer Cells in Primary Biliary Cholangitis

In conclusion NK cells in PBC are sensitive to minute quantities of IL-12 and have a “primed” phenotype. We therefore propose that peripheral priming of NK cells to express tissue-homing markers may contribute to the pathophysiology of PBC.
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research