Pharmaco-epigenomics: On the  Road of Translation Medicine.

Pharmaco-epigenomics: On the Road of Translation Medicine. Adv Exp Med Biol. 2019;1168:31-42 Authors: López-Camarillo C, Gallardo-Rincón D, Álvarez-Sánchez ME, Marchat LA Abstract Epigenomics refers to the study of genome-wide changes in epigenetic mechanisms including DNA methylation, histone modifications and non-coding RNAs expression. The alterations in normal DNA methylation and histone acetylation/deacetylation patterns lead to deregulated transcription and chromatin organization resulting in altered gene expression profiles that facilitates tumor development and progression. In consequence, novel therapeutic strategies aimed at reversing aberrant epigenetic marks in cancer cells have been developed and used in recent molecular studies and clinical trials. Pharmaco-epigenomics is a research area, which refers to the study of epigenome changes in cancer development and how chemotherapeutic agents can reverse these aberrant epigenetic marks by targeting the epigenetic machinery. Besides, the effects of genome-wide polymorphisms in populations leading to variations in drug response are also study subject of pharmaco-epigenomics and are being studied extensively in cancer. Recent findings showed that drug response could be largely influenced by the presence of aberrant epigenetic marks of the whole genome. This implies that biological pathways and cellular processes are under the impact of epigenome status. However, data...
Source: Advances in Experimental Medicine and Biology - Category: Research Tags: Adv Exp Med Biol Source Type: research

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DiscussionWith a look to the possibility of a 5-year survival in patients with a N+ status in level IV and V, the justification for a radical approach to the neck appears questionable. However, modified radical neck dissection appears to be a suitable for a high-risk oral cancer subgroup. A randomised controlled trial is needed to define guidelines for the neck dissection extent in c/pN + cases.
Source: Journal of Cranio Maxillofacial Surgery - Category: ENT & OMF Source Type: research
DiscussionWith a look to the possibility of a 5-year survival in patients with a N+ status in level IV and V, the justification for a radical approach to the neck appears questionable. However, modified radical neck dissection appears to be a suitable for a high-risk oral cancer subgroup. A randomised controlled trial is needed to define guidelines for the neck dissection extent in c/pN+ cases.
Source: Journal of Cranio Maxillofacial Surgery - Category: ENT & OMF Source Type: research
Publication date: March 2020Source: Materials Science and Engineering: C, Volume 108Author(s): Jianhong Liao, Haisheng Peng, Xuan Wei, Yajing Song, Can Liu, Dan Li, Yihua Yin, Xiong Xiong, Hua Zheng, Qun WangAbstractA novel bio-responsive co-delivery system based on Poly(DEA)-b-Poly(ABMA-co-OEGMA) (PDPAO, prepared by reversible addition-fragmentation chain transfer (RAFT) polymerization) copolymers was constructed for enhanced cellular internalization and effective combination therapy. Reduction-sensitive 6-mercaptopurine (6MP) based prodrug and pH-sensitive doxorubicin (DOX) based prodrug were grafted onto PDPAO by an azi...
Source: Materials Science and Engineering: C - Category: Materials Science Source Type: research
Abstract Development of novel tumor-targeted drug vehicles for cancer therapy is very important and has become one of major topics for designing nanoscale chemotherapeutics delivery systems. In the present study, selenium nanoparticles (SeNPs) was decorated with hyaluronic acid (HA) to prepare HA-SeNPs nanoparticles which were used to load doxorubicin (DOX) to fabricate tumor-targeted functionalized selenium nanoparticles HA-Se@DOX. In vitro and in vivo antitumor activities of HA-Se@DOX in human cervical carcinoma treatment were investigated. HA-Se@DOX showed selective cellular uptakes between cervical cancer HeLa...
Source: Appl Human Sci - Category: Physiology Authors: Tags: Mater Sci Eng C Mater Biol Appl Source Type: research
Publication date: March 2020Source: Materials Science and Engineering: C, Volume 108Author(s): Yuehuang Wu, Pengjin Ge, Weixia Xu, Mingyu Li, Qi Kang, Xiaokun Zhang, Jingjing XieAbstractTherapeutic peptide, NuBCP-9 (N9) as a Bcl-2 functional converter, has been demonstrated to have the remarkable anticancer efficiency in Bcl-2-abundant cancer. However, it faced technical challenges in clinical use, such as the low bioavailability, the easily-destroyed bio-stability, and the insusceptibility to cellular interior. With the potential of mesoporous silica nanoparticles (MSNs) as the promising delivery vehicle of therapeutic ma...
Source: Materials Science and Engineering: C - Category: Materials Science Source Type: research
Abstract Herein, we report pH-responsive hydrogels of hierarchically self-assembled protein (zein, in the form of its nanoparticles of size 80-120 nm) and polysaccharide (pectin), where gelation occurred below pH 3 in the absence of crosslinkers, which we used for the encapsulation and release of anticancer drug Doxorubicin (DOX) in the cell nucleus. These nanoparticles, spherical in shape, in addition to helping in the formation of gel network also encapsulate the drug and pectin layer adsorbed on the surface of these nanoparticle allows for the drying, redispersion and enhanced swelling. A monovalent salt-depend...
Source: International Journal of Biological Macromolecules - Category: Biochemistry Authors: Tags: Int J Biol Macromol Source Type: research
Molecular PharmaceuticsDOI: 10.1021/acs.molpharmaceut.9b00717
Source: Molecular Pharmaceutics - Category: Drugs & Pharmacology Authors: Source Type: research
This study provides support for the use of T. camphoratus in the further development of cancer therapy.
Source: Molecules - Category: Chemistry Authors: Tags: Article Source Type: research
A mucoadhesive nanogel is introduced to prolong the residence time and dramatically improve the drug efficiency in local cervical cancer therapy. This nanogel not only displays mucoadhesive properties that adhere strongly to mucins but also contributes to the penetration of drugs in epithelial cell monolayers. The new design with multivalent interactions exerts excellent anticancer activity in cervical cancer. AbstractCervical cancer treatment is subject to limited drug access to locally diseased targets and generally resistant to chemotherapy, thus it is essential to develop a local drug delivery system to overcome these ...
Source: Small - Category: Nanotechnology Authors: Tags: Full Paper Source Type: research
Publication date: November 2019Source: European Polymer Journal, Volume 120Author(s): Bartłomiej Kost, Marek Brzeziński, Marcin Cieślak, Karolina Królewska-Golińska, Tomasz Makowski, Marta Socka, Tadeusz BielaAbstractBiocompatible and biodegradable stereocomplexed micelles (SCMs) based on polylactides (PLAs) with β-cyclodextrin (β-CD) core were designed and used as efficient intracellular drug carriers. The micelles formation, stability and drug release behavior of enantiomeric and stereocomplexed micelles with β-CD core were systematically investigated in comparison to the micelles composed of PL...
Source: European Polymer Journal - Category: Chemistry Source Type: research
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