Mitochondrial Dysfunction Plays a Key Role in the Development of Neurodegenerative Diseases in Diabetes.

Mitochondrial Dysfunction Plays a Key Role in the Development of Neurodegenerative Diseases in Diabetes. Am J Physiol Endocrinol Metab. 2019 Nov 12;: Authors: Cheng H, Gang X, Liu Y, Wang G, Zhao X, Wang G Abstract Mitochondria have an essential function in cell survival due to their role in bioenergetics, reactive oxygen species generation, calcium buffering, and other metabolic activities. Mitochondrial dysfunctions are commonly found in neurodegenerative diseases (NDs), and diabetes is a risk factor for NDs. However, the role of mitochondria in diabetic neurodegeneration is still unclear. In the current study, we reviewed the latest evidence on the role of mitochondrial dysfunctions in the development of diabetes-related NDs and the underlying molecular mechanisms. Hypoglycemic agents, especially metformin, have been proved to have neuroprotective effects in the treatment of diabetes, in which mitochondria could act as one of the underlying mechanisms. Other hypoglycemic agents, including thiazolidinedione (TZDs), dipeptidyl peptidase 4 (DPP-4) inhibitors, and glucagon-like peptide 1 (GLP-1) receptor agonists, have gained more attention due to their beneficial effects on NDs, presumably by improving mitochondrial function. Our review highlighted the notion that mitochondria could be a promising therapeutic target in the treatment of NDs in patients with diabetes. PMID: 31714795 [PubMed - as supplied by publisher]
Source: Am J Physiol Endocri... - Category: Endocrinology Authors: Tags: Am J Physiol Endocrinol Metab Source Type: research