Tocilizumab Effects on Coagulation Factor XIII in Patients with Rheumatoid Arthritis

AbstractIntroductionRheumatoid arthritis (RA) is a chronic systemic auto-immune disease associated with a prothrombotic state. Tocilizumab, an interleukin-6 receptor inhibitor, is highly effective in controlling disease activity and thrombotic risk. Factor XIII (FXIII), involved in thrombotic complications, has been reported to be reduced in RA patients during maintenance treatment with tocilizumab, but no data are available before and after the drug administration. Thus, we investigated the effects of tocilizumab on FXIII, thrombin generation and inflammation in patients with RA na ïve for the drug.MethodsWe studied 15 consecutive adult patients with RA at baseline and 4 weeks after the onset of parenteral administration of tocilizumab, measuring disease activity and plasma levels of C-reactive protein (CRP), FXIII, and prothrombin fragments F1+2 by immunoenzymatic methods. Fifteen healthy subjects, sex-and age-matched with patients, served as normal controls for laboratory measurements.ResultsAt baseline, patients with established RA had a median DAS28 of 4.8 (3.2 –8.3) and, compared to healthy controls, had higher plasma levels of CRP (p 
Source: Advances in Therapy - Category: Drugs & Pharmacology Source Type: research

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Conditions:   Autoimmune Disorder;   Rheumatoid Arthritis;   Systemic Lupus Erythematosus;   Primary Sjögren's Syndrome Interventions:   Drug: branebrutinib;   Drug: abatacept;   Drug: branebrutinib placebo Sponsor:   Bristol-Myers Squibb Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Condition:   Arthritis, Rheumatoid Intervention:   Drug: Golimumab Sponsor:   Peking Union Medical College Hospital Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Publication date: Available online 4 December 2019Source: Joint Bone SpineAuthor(s): Chang-Fu Kuo, Patricia B. Burns, Jung-Sheng Chen, Lu Wang, Kevin C. ChungAbstractObjective: The purpose of the study is to investigate the risk of preventable hospitalization among patients with rheumatoid arthritis (RA).Methods: We identified 11,852 incident RA patients and 59,260 age-, sex-, and index year-matched controls from the Taiwan National Health Insurance Database. Index date was the RA diagnosis date for cases, which was assigned to their matched controls. The odds ratios (OR) of preventable hospitalizations between RA patients...
Source: Joint Bone Spine - Category: Orthopaedics Source Type: research
Abstract The skin is the largest human organ, comprising the epidermis that is composed of epithelial tissue, the dermis composed of connective tissue, and the innermost subcutaneous tissue. Generally, skin conditions are due to aging and the influence of the external environment, but empirically patients with gastrointestinal diseases are more prone to pruritus and inflammation caused by dry skin. A decrease in the skin barrier function, involving immunocompetent mast cells and oxidative stress, was noted in indomethacin-induced small intestine inflammation, dextran sodium sulfate (DSS)-induced ulcerative colitis...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - Category: Drugs & Pharmacology Authors: Tags: Yakugaku Zasshi Source Type: research
In conclusion, the results suggest that the recurrence of GBM is associated with high gene expression levels VEGFA and CXCL8, and the development of the central nervous system. PMID: 31788092 [PubMed]
Source: Oncology Letters - Category: Cancer & Oncology Tags: Oncol Lett Source Type: research
Authors: Kwak JM, Koh KH, Jeon IH Abstract Total elbow arthroplasty is a common surgical procedure used in the management of advanced rheumatoid arthritis, posttraumatic arthritis, osteoarthritis, and unfixable fracture in elderly patients. Total elbow prostheses have evolved over the years and now include the linked, unlinked, and convertible types. However, long-term complications, including infection, aseptic loosening, instability, and periprosthetic fracture, remain a challenge. Here, we introduce each type of implant and evaluate clinical outcomes and complications by reviewing the previous literature. PM...
Source: Clinics in Orthopedic Surgery - Category: Orthopaedics Tags: Clin Orthop Surg Source Type: research
ConclusionsThis study provides novel insight into the perspectives of patients with rheumatoid arthritis on tapering biologics when sustained remission is achieved at a crucial juncture in global affordability for healthcare systems. These patient perspectives can inform the planning of decision aids and clinical trials of decision-making processes when tapering is proposed.
Source: The Patient - Patient-Centered Outcomes Research - Category: International Medicine & Public Health Source Type: research
AbstractPurpose of ReviewTo review how peripheral inflammation in rheumatic disease influences the central nervous system. We consider recent studies of rheumatic disease that employ functional and structural neuroimaging in the context of inflammation, as well as recent studies considering how immunosuppressive therapy is associated with changes in brain function and structure.Recent FindingsThe most compelling evidence thus far comes from studies of rheumatoid arthritis and indicates that higher levels of inflammation are associated with changes in cognitive, affective, and pain-processing brain regions, some of which ma...
Source: Current Rheumatology Reports - Category: Rheumatology Source Type: research
Authors: Mankia K, Briggs C, Emery P Abstract Early referral and initiation of disease-modifying antirheumatic drugs (DMARD) is associated with better outcomes for patients with rheumatoid arthritis (RA)1,2 In the United Kingdom, general practitioners (GP) are advised to refer patients with suspected RA urgently3 and rheumatology departments are rewarded for timely management of these patients4. PMID: 31787610 [PubMed - as supplied by publisher]
Source: Journal of Rheumatology - Category: Rheumatology Tags: J Rheumatol Source Type: research
Authors: Deane KD, Demoruelle MK Abstract In the letter by Alpizar-Rodriguez and Finckh1, they describe their prior work in which they found, similar to our current report, an association between older age and anticitrullinated protein antibody (ACPA) positivity in first-degree relatives (FDR) of patients with rheumatoid arthritis (RA)2,3 In contrast to our findings, their data suggest that the strongest association between ACPA positivity and age is in women aged 45-55 years, and they did not find an association between ACPA positivity and age in men. PMID: 31787609 [PubMed - as supplied by publisher]
Source: Journal of Rheumatology - Category: Rheumatology Tags: J Rheumatol Source Type: research
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