Salivary proteins from dysplastic leukoplakia and oral squamous cell carcinoma and their potential for early detection.

Salivary proteins from dysplastic leukoplakia and oral squamous cell carcinoma and their potential for early detection. J Proteomics. 2019 Nov 07;:103574 Authors: Sivadasan P, Gupta MK, Sathe G, Sudheendra HV, Sunny SP, Renu D, Hari PS, Harsha HC, Suresh A, Kuriakose MA, Sirdeshmukh R Abstract Dysplastic leukoplakia (LP) of the oral cavity is a potentially malignant condition for oral squamous cell carcinoma (OSCC), early detection of which remains an unmet clinical need. In an effort to develop non-invasive biomarker based method for early detection of the disease, differential proteomic profiling was carried out with the saliva from patients with risk habits and diagnosed with LP and those with lymph node negative and positive OSCC in comparison to healthy controls with risk habits. Ninety three proteins were observed at elevated level (≥1.5 fold), and 30 were prioritized based on a scoring system comprising of confidence of identification, presence in the various specimen groups, functional relevance, and their secretory potential. Verification was carried out in independent patient cohorts for 8 selected, representative, upregulated proteins using ELISA. Three of them CD44, S100A7, and S100P were significantly altered in patients with LP as well as OSCC and can be regarded as a panel of biomarker candidates for early detection of the malignancy. Other members may also be investigated in a targeted manner to expand the portfolio...
Source: Journal of Proteomics - Category: Biochemistry Authors: Tags: J Proteomics Source Type: research