Lytic Bacteriophage Screening Strategies for Multidrug-Resistant Bloodstream Infections in a Burn Intensive Care Unit.

CONCLUSIONS The causative organisms of BSI and the presence of MDR in a hospital BICU were not typical, which supports the need for routine bacterial monitoring. Hospital sewage provides a potential source of bacteriophage for the treatment of MDR pathogenic bacteria. PMID: 31693655 [PubMed - in process]
Source: Medical Science Monitor - Category: Research Tags: Med Sci Monit Source Type: research

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In this study, gold nano-star was synthesized and used for bio-conjugation with pDNA toward the detection of target sequences. Synthesized probe (5ʹ TTG TGA ACT ATT TAC GTC AGC ATG C3ʹ) of Acinetobacter baumannii was found with excellent sensitivity. After the hybridization of pDNA with cDNA, target DNA (5ʹ GCA TGC TGA CGT AAA TAG TTC ACA A 3ʹ) was easily measured. According to ultra-sensitivity of the engineered optical DNA-based bio-assay, it is potentially applied in the bacterial detection of the environmental and clinical specimens. Here, the selection of engineered biosensor in the presence of two mismatch sequen...
Source: Enzyme and Microbial Technology - Category: Biotechnology Source Type: research
AbstractThe increasing prevalence of multidrug-resistant strains ofMycobacterium tuberculosis (Mtb), the pathogen of human tuberculosis (TB), serves as a strong incentive for the discovery and development of new agents for the treatment of this plight. In search for such drugs, we investigated a series of benzyltriazole derivatives. We herein report the design, synthesis and biological activity of disubstituted benzyltriazoles against the human virulent H37Rv strain ofMtb as well as the toxicity on human embryonic kidney (HEK-293) cells. The derivative21 featuring trifluoromethyl substituent inpara position on the phenyl r...
Source: Medicinal Chemistry Research - Category: Chemistry Source Type: research
Publication date: Available online 12 November 2019Source: Journal of Photochemistry and Photobiology B: BiologyAuthor(s): Violet Vakunseh Bumah, Daniela Santos Masson-Meyers, Chukuka Samuel EnwemekaAbstractIn our recent study, we showed that pulsed blue light (PBL) suppresses the growth of Propionibacterium acnes more than continuous wave (CW) blue light in vitro, but it is not known that other bacteria, such as methicillin-resistant Staphylococcus aureus (MRSA), respond similarly to PBL. The high potency of PBL relative to CW blue light makes it a suitable antimicrobial for suppressing bacterial growth in biofilms as wel...
Source: Journal of Photochemistry and Photobiology B: Biology - Category: Speech-Language Pathology Source Type: research
The meet-cute is neatly postponed in this entertaining story of two next-door neighbours, both seeing therapists and looking for loveMuch like the process of psychotherapy itself, patience is required for results while watching this modestly entertaining slow-burn Parisian romance fromC édric Klapisch, who pulls off a neat trick by bumping the meet-cute to the end of the film.What happens before his protagonists clap eyes on each other is a kind of emotional spring clean. Both of them, a man and woman in their early 30s, are struggling with anxiety and stress; they find their way to therapy and sift through their se...
Source: Guardian Unlimited Science - Category: Science Authors: Tags: Romance films Psychology France World news Science Europe Culture Paris Source Type: news
Publication date: Available online 13 November 2019Source: Arthroscopy TechniquesAuthor(s): Burak Altintas, Frank Martetschläger, Erik M. Fritz, Ryan J. Warth, Joshua A. Greenspoon, Travis C. Burns, Nicole L. Anderson, Peter J. MillettAbstractSurgical exposure of the glenoid after previous coracoid process transfer is technically challenging as a result of distorted anatomy, obliterated soft-tissue planes, and adhesive scar tissue, which poses additional risk to adjacent neurovascular structures. The purpose of this article is to present a technique for glenoid exposure following coracoid transfer that involves tenoto...
Source: Arthroscopy Techniques - Category: Surgery Source Type: research
ConclusionsTherapeutic drug monitoring-guided meropenem may be a sound new therapeutic option in eradicating multidrug resistant Acinetobacter and offer a novel therapeutic option in the field of personalized medicine.
Source: Respiratory Medicine Case Reports - Category: Respiratory Medicine Source Type: research
The objective of this clinical study was to evaluate the efficacy of a vaginal CO2 laser treatment (CO2RE Intima) in patients with moderate, severe and very severe stress urinary incontinence (SUI) or mixed urinary incontinence (MUI), as well as its impact in sexual relations.DesignThis was a single-center, prospective, interventional study that included 25 women aged 35-68 years who presented with moderate, severe and very severe symptoms of SUI or MUI, based on Sandvik index and ICIQ-UI scores. A series of three fractional micro-ablative CO2 vaginal laser treatment sessions was performed, each spaced 4 to 6 weeks apart. ...
Source: European Journal of Obstetrics and Gynecology and Reproductive Biology - Category: OBGYN Source Type: research
ConclusionGrill-related injuries are a relatively common cause of admission to the Cologne Burn Center. Although grill-related injuries underwent a less aggressive approach than the other investigated fire injuries, the former represent a public health concern because they mainly affect the upper body, with both psychologic and aesthetic consequences. We recommend a German nationwide multi-centric study of the patterns and characteristics of burn injury.
Source: Burns - Category: Dermatology Source Type: research
ConclusionsThis study provides the largest description of first aid use in sub-Saharan Africa, strengthening the evidence that remedies aside from water are commonly used and that higher parental education levels do not translate to increased use of water, but rather use of alternative treatments. Our qualitative findings allow improved understanding of how first aid for paediatric burns is perceived in rural Malawi communities, providing insight as to why certain first aid choices are made and the possible barriers and facilitators to the adoption of water as a first aid treatment.
Source: Burns - Category: Dermatology Source Type: research
Publication date: Available online 13 November 2019Source: BurnsAuthor(s): Colleen M. Ryan, Jeffrey C. Schneider, James C. Jeng
Source: Burns - Category: Dermatology Source Type: research
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