Sensitizing gastric adenocarcinoma to chemotherapy by pharmacological manipulation of drug transporters.

In conclusion, MRP1 and MRP4 play an important role in the lack of response of GAC to drugs that are transported by these export pumps. Moreover, agents, such as sorafenib, considered at present useless to treat GAC, may become active antitumor drugs when co-administered with non-toxic MRP inhibitors, such as diclofenac.
PMID: 31669256 [PubMed - as supplied by publisher]

Source: Biochemical Pharmacology - October 23, 2019 Category: Drugs & Pharmacology Authors: Al-Abdulla R, Perez-Silva L, Lozano E, Macias RIR, Herraez E, Abad M, Segues N, Bujanda L, Briz O, Marin JJG Tags: Biochem Pharmacol Source Type: research