Epigenetic Dysregulation of Dopaminergic System by Maternal Cafeteria Diet During Early Postnatal Development

Publication date: Available online 1 November 2019Source: NeuroscienceAuthor(s): M.F. Rossetti, R. Schumacher, M.P. Gastiazoro, G.P. Lazzarino, M.F. Andreoli, C. Stoker, J. Varayoud, J.G. RamosAbstractDopamine is a neurotransmitter crucial for motor, motivational, and reward-related functions. Our aim was to determine the effect of a palatable maternal diet on the transcriptional regulation of dopaminergic-related genes during perinatal development of the offspring. For that, female offspring from dams fed with a control (CON) or a cafeteria (CAF) diet were sacrificed on embryonic day 21 (E21) and postnatal day 10 (PND10). Using micropunch techniques, ventral tegmental area (VTA) and nucleus accumbens (NAc) were isolated from brain’s offspring. Bioinformatic analysis of the promoter regions, mRNA quantification and methylation studies were done. The increase in tyroxine hidroxylase (TH), dopamine receptor (DRD) 1 and ghrelin receptor (GHSR) expression in VTA and NAc from E21 to PND10 was correlated with changes in DNA methylation of their promoter regions. Maternal diet did not affect the expression patterns in E21. At PND10, maternal CAF diet decreased the transcription of TH, GHSR, DRD2 and dopamine transporter (DAT) in VTA. Interestingly, the changes in TH, DRD2 and DAT expression were related to the methylation status of their promoters. In NAc, maternal CAF diet reduced DRD1, DRD2 and DAT expression in the offspring at PND10, although alternations in the ...
Source: Neuroscience - Category: Neuroscience Source Type: research

Related Links:

Obesity and being overweight have become a worldwide epidemic affecting more than 1.9 billion adults and 340 million children. Efforts to curb this global health burden by developing effective long-term non-surgical weight loss interventions continue to fail due to weight regain after weight loss. Weight cycling, often referred to as Yoyo dieting, is driven by physiological counter-regulatory mechanisms that aim at preserving energy, i.e. decreased energy expenditure, increased energy intake, and impaired brain-periphery communication. Models based on genetically determined set points explained some of the weight control m...
Source: Frontiers in Genetics - Category: Genetics & Stem Cells Source Type: research
DISCUSSION: We expect that the FADK Project will contribute significantly to our understanding of FA. PMID: 31796135 [PubMed - in process]
Source: Acta Neuropsychiatrica - Category: Psychiatry Tags: Acta Neuropsychiatr Source Type: research
Conclusion: Safer prescribing policies may take multiple years to fully implement and need to be employed across the jurisdiction to minimize doctor-shopping and adverse effects on patients with chronic pain. Approaching pain management through the social-ecological model can address potential root causes of addiction and establish a framework for doctors to provide compassionate care, community leadership, and advocacy for these patients. PMID: 31790125 [PubMed - in process]
Source: Journal of the American Osteopathic Association - Category: Complementary Medicine Tags: J Am Osteopath Assoc Source Type: research
ConclusionsBoth parents and clinicians should be aware of the widespread phenomenon of media device use among adolescents and try to avoid psychophysical consequences on the youngest.
Source: Italian Journal of Pediatrics - Category: Pediatrics Source Type: research
Life expectancy among people living in the United States has fallen in recent years, driven in part by an uptick in deaths among young and middle-aged adults from drug overdose, alcohol consumption, and suicide, according to areport published today inJAMA.“The implications of increasing midlife mortality are broad, affecting working-age adults and thus employers, the economy, health care, and national security. The trends also affect children, whose parents are more likely to die in midlife and whose own health could be at risk when they reach that age, or sooner,” wrote Steven Woolf, M.D., M.P.H., and Heidi Sc...
Source: Psychiatr News - Category: Psychiatry Tags: alcohol CDC drug overdose Heidi Schoomaker Howard K. Koh JAMA Mental Health Parity and Addiction Equity Act of 2008 middle-aged adults Steven Woolf suicide U.S. life expectancy young adults Source Type: research
These days, you can’t go anywhere without hearing about how technology is ruining everything, including our happiness. There is some truth to this, but it’s not the whole story. Technology can be bad for us—for example, when social media gives us FOMO (fear of missing out) or traps us in filter bubbles that prevent us from seeing multiple points of view on important issues. As a society, we are increasingly concerned that technologies like smartphones and social media result in more social comparison, bullying, and loneliness—all stumbling blocks to happiness. Technology seems to be bad for our happ...
Source: SharpBrains - Category: Neuroscience Authors: Tags: Cognitive Neuroscience Education & Lifelong Learning Health & Wellness Technology boost your health CBT cognitive-behavioral-therapy depression digital detox emotion regulation Facebook Gratitude happiness mental health challenge Source Type: blogs
This article is excerpted from TIME: The Science of Addiction—What We Know. What We’re Learning. In some ways, of course, food is more insidious than drugs, because there’s no such thing as abstinence, no such thing as never starting in the first place, no such thing as being able to say, “Food? Never touch the stuff.” You eat because you’ll die if you don’t, so you spend your life in a sort of nutritional two-step—a little but not too much; go overboard today, cut back tomorrow; eat the good stuff but never the junk. Sometimes you succeed at all of that, and other times yo...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized Addiction Diet/Nutrition Obesity Source Type: news
Abstract Butyrylcholinesterase is a serine hydrolase that catalyzes the hydrolysis of esters in the body. Unlike its sister enzyme acetylcholinesterase, butyrylcholinesterase has a broad substrate scope and lower acetylcholine catalytic efficiency. The difference in tissue distribution and inhibitor sensitivity also points to its involvement external to cholinergic neurotransmission. Initial studies on butyrylcholinesterase showed that the inhibition of the enzyme led to the increment of brain acetylcholine levels. Further gene knockout studies suggested its involvement in the regulation of amyloid-beta, a brain p...
Source: Current Protein and Peptide Science - Category: Biochemistry Authors: Tags: Curr Protein Pept Sci Source Type: research
In the beginning, there were single-cell bacteria. They were the only life on earth for billions of years, then larger cells evolved, then multicellular organisms, and then plants and animals. But the bacteria never went away, and all organisms, including us humans, have had to learn to live with them. Today, the lessons they are teaching us could change the trajectory of human health for generations. When bacteria were first discovered more than three centuries ago, most attention was on the ones we fought, which caused diseases like cholera, typhoid and tuberculosis. Through vaccines and antibiotics, we have made amazing...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized medicine Source Type: news
Orexins [orexin-A (OXA) and orexin-B (OXB)] are two isoforms of neuropeptides produced by the hypothalamus. The main biological actions of orexins, focused on the central nervous system, are to control the sleep/wake process, appetite and feeding, energy homeostasis, drug addiction, and cognitive processes. These effects are mediated by two G protein-coupled receptor (GPCR) subtypes named OX1R and OX2R. In accordance with the synergic and dynamic relationship between the nervous and immune systems, orexins also have neuroprotective and immuno-regulatory (i.e., anti-inflammatory) properties. The present review gathers recen...
Source: Frontiers in Endocrinology - Category: Endocrinology Source Type: research
More News: Addiction | Brain | Diets | Eating Disorders & Weight Management | Genetics | Neurology | Neuroscience | Nutrition | Obesity | Perinatology & Neonatology | Study