Blocking Complement Factor B Activation Reduces Renal Injury and Inflammation in a Rat Brain Death Model

Conclusion: This study shows that donor pretreatment with anti-FB preserved renal function, reduced renal damage and inflammation prior to transplantation. Therefore, inhibition of factor B in organ donors might be a promising strategy to reduce brain death-induced renal injury and inflammation.
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research