Mediators of the Effects of Canagliflozin on Heart Failure in Patients With Type 2 Diabetes

ConclusionsA diverse set of potential mediators of the effect of canagliflozin on heart failure were identified. Some mediating effects were anticipated, whereas others were not. The mediators that were identified support existing and novel hypothesized mechanisms for the prevention of heart failure with sodium glucose cotransporter 2 inhibitors.Central Illustration
Source: JACC: Heart Failure - Category: Cardiology Source Type: research