Adipose ‑derived stem cells overexpressing SK4 calcium‑activated potassium channel generate biological pacemakers.

In conclusion, SK4 induced ADSCs to differentiate into cardiomyocyte‑like and pacemaker‑like cells via activation of the extracellular signal‑regulated kinase 1/2 and p38 mitogen‑activated protein kinase pathways. Therefore, ADSCs transduced with SK4 may be used to generate biological pacemakers in ex vivo rat hearts. PMID: 31638180 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/31638180?dopt=Abstract

Source: International Journal of Molecular Medicine - October 15, 2019 Category: Molecular Biology Authors: Yang M, Zhao Q, Zhao H, Yang A, Wang F, Wang X, Tang Y, Huang C Tags: Int J Mol Med Source Type: research